ALL YOU WANT TO KNOW IN MEDICINAL CHEMISTRY Name Email * NEW DRUG APPROVALS, ANTHONY CRASTO DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO https://newdrugapprovals.org/ DR ANTHONY MELVIN CRASTO ALL ABOUT DRUGS, by
The influence of drug-like concepts on decision-making in medicinal chemistry. Nature Rev. Drug Discov. 6, 881–890 (2007). CAS Google Scholar Vicens, M. et al. Novel cationic and neutral glycocholic acid and polyamine conjugates able to inhibit transporters involved in hepatic and intestinal...
Donepezil is a long-acting drug and does not exhibit the adverse events, especially hepatotoxicity, associated with tacrine. The safety and tolerability features and efficacy of several other investigational drugs including metrifonate, rivastigmine (ENA 713), eptastigmine, galantamine (galanthamine) and...
Multiple studies have shown that the use of ENDSs to inhale marijuana is more popular among school students aged 14–18 years than among middle school students or adults [9,22]. Previous research suggested that nicotine and THC may enhance each other's effects by acting synergistically on the ...
Benztropine has three rings each connected to a carbon atom acting as a hub (Figure 2). Molecule A has well-defined electron density and binds with one phenyl ring nestling in a subpocket adjacent to α3, delimited by side-chains of residues I38 and I43 of the β1−β2 hairpin, L...
There is a report indicating that the removal of the intravascular catheter reduces the mortality rate; however, if it is not possible, antifungal drugs acting against biofilms, such as echinocandins and liposomal amphotericin B, should be used [22]. In the case of C. albicans, antifungal ...
After several years as a postdoctoral fellow in medicinal chemistry at Rheinische Friedrich-Wilhelms-Universität in Bonn/Germany, he joined the Fraunhofer Institute for Technological Trend Analysis INT in Euskirchen/Germany as a senior scientist in 2007. Since 2014, he heads the business unit “...
Clinical studies are lacking. The CNS stimulant effects of 1 nut have been reported to be equal to or greater than effects of the caffeine content of 2 large cups of coffee.(Burdock 2009)Erectile dysfunction In a study documenting medicinal plants used in the treatment of sexual impotence and...
Fluparoxan: A comprehensive review of its discovery, adrenergic and cns activity and treatment of cognitive dysfunction in central neurodegenerative diseases 2017, Mini-Reviews in Medicinal Chemistry Medications development for substance-use disorders: Contextual influences (dis)incentivizing pharmaceutical-indus...
Thus, the discovery of anti-epileptic drugs that interfere with GABA activity has been a challenge in medicinal chemistry, which has led to the development of different anticonvulsant drugs such as: phenobarbital, benzodiazepines (e.g. diazepam, midazolam, ganaloxone and stiripentol, acting directly ...