Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells. Nucleic Acids Res. 2013; 41(Database issue):D955-61.Yang, W., Soares, J., Greninger, P., Edelman, E.J., Lightfoot, H., Forbes, S., Bindal, N., Beare, D., Smith, J...
In order to evaluate the accuracy of our network further, we computed the rate at which the most effective drug predicted by our model in terms that the predicted drug response was in fact the recommended drug for that cancer cell type. To this end, we defined Top-1 and Top-3 candidates...
Alterations in cancer genomes strongly influence clinical responses to treatment and in many instances are potent biomarkers for response to drugs. The Genomics of Drug Sensitivity in Cancer (GDSC) database(www.cancerRxgene.org) is the largest public resource for information on drug sensitivity in ...
Using drug response data collected in the Cancer Cell Line Encyclopedia (CCLE) and the Genomics of Drug Sensitivity in Cancer (GDSC), we determined the optimal functional form for each drug. Then, a NLME model was fit to the drug response data, with the estimated random effects used to ...
1. Schematic in a created with BioRender.com. Full size image Cancer cell models had enhanced sensitivity to gRNAs targeting their specific driver oncogenes. PC9 cells were most sensitive to deleterious edits in EGFR, whereas HT-29 were most sensitive to deleterious edits in BRAF, and both ...
The drug sensitivity analysis was based on the Genomics of Drug Sensitivity in Cancer (GDSC) database [18]. GSVA analysis and construction of a ceRNA Network Gene set variation analysis (GSVA) is an unsupervised and nonparametric method for assessing the enrichment of gene sets associated with ...
1. Schematic in a created with BioRender.com. Full size image Cancer cell models had enhanced sensitivity to gRNAs targeting their specific driver oncogenes. PC9 cells were most sensitive to deleterious edits in EGFR, whereas HT-29 were most sensitive to deleterious edits in BRAF, and both ...
Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells. Nucleic Acids Res. 41, D955–D961 (2013). Article CAS Google Scholar Shoemaker, R.H. The NCI60 human tumour cell line anticancer drug screen. Nat. Rev. Cancer 6, 813–823 (...
Sensitivity analysis of anticancer drugs Genomics of Drug Sensitivity in Cancer (GDSC; https://www.cancerrxgene.org/), which is used for molecular cancer therapy and mutation, was used to explore public databases [34]. R's pRRophetic package was used to download cell line gene mutation data...
Chemotherapy response to various drugs for each sample in TCGA-PRAD was predicted using the Genomics of Drug Sensitivity in Cancer (GDSC) website. The prediction was carried out through the R package pRRophetic, which estimated the IC50 of the samples using ridge regression. Constructing ...