Cancer researchYang W, Soares J, Greninger P, Edelman EJ, Lightfoot H, Forbes S, et al. Genomics of Drug Sensitivity in Cancer (GDSC): A resource for therapeutic biomarker discovery in cancer cells. Nucleic Acid
The Genomics of Drug Sensitivity in Cancer Project (GDSCP) seeks to identify optimal interventions for specific cancer genetic features by assessing the sensitivity profile of over 1000 genomically and transcriptionally characterized cancer cell lines to a large panel of chemotherapeutic agents and ...
Alterations in cancer genomes strongly influence clinical responses to treatment and in many instances are potent biomarkers for response to drugs. The Genomics of Drug Sensitivity in Cancer (GDSC) database(www.cancerRxgene.org) is the largest public resource for information on drug sensitivity in ...
Genomics of Drug Sensitivity in Cancer (GDSC) tools including pipelines related tohttp://www.cancerrxgene.org/ pip install gdsctools For beginners, please visit the main documentationInstallationsection. QuickStart You will need 2 input matrices: ...
Building on the NCI-60 paradigm (Abaan et al., 2013, Reinhold et al., 2012, Reinhold et al., 2015, Reinhold et al., 2017, Zoppoli et al., 2012), pharmacogenomic data portals such as the Genomics of Drug Sensitivity in Cancer (GDSC) (Garnett et al., 2012, Iorio et al., 2016...
Neighborhood component analysis (NCA), a supervised feature selection algorithm selected relevant features from multi-omics datasets retrieved from The Cancer Genome Atlas (TCGA) and Genomics of Drug Sensitivity in Cancer (GDSC) databases. A Neural network framework, fed with NCA selected features, ...
Genomics of Drug Sensitivity in Cancer (GDSC) a resource for… 热度: The impact of information technology on the human resource professional 热度: MOsDB: an integrated information resource for rice genomics Wojciech M. Karlowski, Heiko Schoof, Vijayalakshmi Janakiraman, Volker Stuempflen ...
GDSC: Genomics of Drug Sensitivity in Cancer OS: Overall survival HBV: Hepatitis B Virus. HCV: Hepatitis C Virus. BP: Biological process CC: Cellular component MF: Molecular function PRRS: PPP-related risk score DCA: Decision curve analysis APC: Antigen-presenting cell MHC: Major ...
Drug information was sourced from the Genomics of Drug Sensitivity in Cancer database (GDSC, https://www.cancerrxgene.org/). The top 10 drugs with significantly higher or lower IC50 values between the two risk groups were visualized using the “ggplot2” package (v 3.4.1)....
Large-scale HTS studies such as Cancer Cell Line Encyclopedia (CCLE)[18], Genomics of Drug Sensitivity in Cancer (GDSC)[19, 20], Cancer Therapeutics Response Portal (CTRP)[21], and NCI-60 Developmental Therapeutic Program Screen[22]represent examples of the HTS pharmacological profiling data ...