Beyond trough:peak ratio: A new index of the smoothness of the antihypertensive effect of a drugdoi:10.1016/0895-7061(96)82040-1SDOSAmerican Journal of Hypertension
The trough:peak ratio provides a clinically relevant index for assessing whether an anti-hypertensive drug is likely to provide a consistent anti-hypertensive effect throughout the 24 h. 展开 关键词: hypertension trough, peak ratio 被引量: 14 ...
Compared to trough-only-based TDM, peak-trough-based TDM was associated with less vancomycin total daily doses by 12.05mg/kg/day (p value=0.027). CART identified creatinine clearance (CL CR ), AUC 24 /MIC, and TDM approach as significant determinants of therapeutic outcomes. All patients [...
it is often recommended to prescribe so-called “forgiving” drugs, which maintain their effect despite lapses in patient adherence. Nevertheless, drug forgiveness is difficult to quantify and compare between different drugs. In this
A Real-World Matched Cohort Study of the Effect of Concomitant Amiodarone or Diltiazem Administration on Apixaban Peak and Trough Concentrations Background:Apixaban is a substrate for p-glycoprotein and is extensively metabolized by cytochrome P450 (CYP)3A4. There are minimal published data regardin....
Please read and reflect. Make sure we are executing to this in each of our sites on daily basis – this applies not only to peak although especially impactful at NAFC peak. FYI. 戴维真正地是一位老练的FC领导。 那些点不错打开。 请读并且反射。 确定我们执行对此在每一个我们的站点根据每日...
[93,104] and dose adjustments seem unnecessary. Interestingly, in a clinical case report of an obese patient who presented with an ischaemic stroke whilst on dabigatran, substitution to rivaroxaban lead to peak and trough rivaroxaban levels consistent with effective anticoagulation [93], suggesting ...
Tobramycin serum concentrations (peak and trough) were measured by enzyme multiplied immunoassay. The renal and auditorory functions of the patients were monitored before, during and immediately after treatment. Results: The two groups were comparable with respect to sex, age, body weight and renal ...
Peak (model predicted) and trough plasma concentrations were 4.75 to 6.20 micrograms/ml and less than 0.25 to 0.63 microgram/ml, respectively, in patients receiving 2.5 mg/kg. Peak concentrations are well above those needed to inhibit HCMV at the 50% level (ID50) and troughs are near this...
Zokufa HZ et al. Simulation of vancomycin peak and trough concentrations using five dosing methods in 37 patients. Pharmacotherapy 1989; 9(1): 10–16 PubMedCASGoogle Scholar Literatur Addis GL, Johnston DA. Controversies in Therapeutics: Theophylline in the management of airflow obstruction. Br ...