由于催化反应时酶对底物化学结构有一定的要求,因此不同化学结构的药物,其代谢的情况不同。 药物代谢的酶 Enzymes for Drug Metabolism 第I相生物转化是官能团化反应,是在体内多种酶系的催化下,对药物分子引入新的官能团或改变原有的官能团的过程。参与药物体内I相生物转化的酶类,主要是氧化-还原酶和水解酶。 细胞...
网络药物代谢酶 网络释义 1. 药物代谢酶 2.药物代谢酶药物在体内的转化是在酶的催化下进行,这些催化药物转化的酶,统称为药物代谢酶(drug metabolism enzyme… book.jd.com|基于13个网页
Drug Metabolism: Other Phase I EnzymesGianluca CatucciGianfranco GilardiSheila J. SadeghiComprehensive Pharmacology
Liver slices retain intact cell–cell junctions, cellular integrity, and the complete array of drug metabolizing enzymes compared to other in vitro systems. Thus, liver slices are attracting increasing attention since complete information on drug metabolism reaction can be obtained in this system. Recom...
Most drugs are given at concentrations smaller than the Km of the enzymes of their metabolism. Zero Order Metabolism A drug may be given in doses that produce blood concentrations greater than the Km of the enyzme for the drug. v = Vmax [C] K m + [C] When [C] >>> Km, then v...
How will you examine drug metabolism in the body? It has been shown that if you take a faecal sample from a person with depression and transplant that sample into a healthy rat, the rat will begin o show signs of depressive illness. We plan to build on this and will transplant our huma...
163Gut microbiota can directly affect drug metabolism in several manners, including generating enzymes that degrade or catalyze a drug molecule, competing with drug molecules for a metabolic enzyme, altering the metabolic levels of drugs in the host, or generating enzymes that stimulate metabolites ...
DrugMetabolism Extrahepaticmicrosomalenzymes (oxidation,conjugation)Hepaticmicrosomalenzymes (oxidation,conjugation)Hepaticnon-microsomalenzymesnon(acetylation,sulfation,GSH,alcohol/aldehydedehydrogenase,hydrolysis,ox/red)LiverMicrosomalSystem OxidativeReactions:CytochromeP450mediated••Examples –Formationofaninactivepolar...
•Define the various superfamilies, subfamilies, and individual drug-metabolizing enzymes and their tissue expression in humans. •Identify the role of the major drug-metabolizing enzymes in the disposition of medication and other xenobiotics...
(or other xenobiotic) substrates under steady-state conditions, human fetal drug metabolism probably is of little consequence in most cases, although exceptions may exist. Pharmacokinetic parameters observed after isolated exposure, however, are very likely to be affected, perhaps markedly, in some ...