药物代谢的酶 Enzymes for Drug Metabolism 第I相生物转化是官能团化反应,是在体内多种酶系的催化下,对药物分子引入新的官能团或改变原有的官能团的过程。参与药物体内I相生物转化的酶类,主要是氧化-还原酶和水解酶。 细胞色素P-450酶系(Cytochrome P-450 Enzyme System) 细胞色素 P-450酶系(cytochrome P-450 ...
Drug Metabolism: Other Phase I EnzymesGianluca CatucciGianfranco GilardiSheila J. SadeghiComprehensive Pharmacology
网络药物代谢酶 网络释义 1. 药物代谢酶 2.药物代谢酶药物在体内的转化是在酶的催化下进行,这些催化药物转化的酶,统称为药物代谢酶(drug metabolism enzyme… book.jd.com|基于13个网页
The Interference of Pharmaceuticals with Endogenous and Xenobiotic Metabolizing Enzymes in Carp Liver: An ln-Vitro Study. metabolism in fish, were investigated in-vitro by incubating carp liver subcellular fractions in the presence of the substrate and the selected drug. Anti... Thibaut,Rémi,Schnell...
The frequency of occurrence of CYP allelic variants among various ethnic and other subgroups continue to be characterized. CYP2D6, CYP2C9, and CYP2C19 are among the most highly polymorphic of all CYP enzymes. Of these, the polymorphism of CYP2D6, which is responsible for the metabolism of ~...
Enzymes-for-Drug-Metabolism网络药物代谢的酶 网络释义 1. 药物代谢的酶 ...ture and Metabolism) 第二节 药物代谢的酶(Enzymes for Drug Metabolism)第Ⅰ相生物转化是官能团化反应,是在体内多种 …www.eapoo.com|基于3个网页© 2025 Microsoft 隐私声明和 Cookie 法律声明 广告 帮助 反馈...
Chasseaud, L.F.: Distribution of enzymes that catalyze reactions of glutathione with α, β-unsaturated compounds. Biochemical Journal 131: 765–769 (1973). PubMedCASGoogle Scholar Connors, T.A.: Bioactivation and cytotoxicity; in Bridges and Chasseaud (Eds) Progress in Drug Metabolism, Vol. ...
Cytochromes \\{P450\\} (CYP) are a major source of variability in drug pharmacokinetics and response. Of 57 putatively functional human \\{CYPs\\} only about a dozen enzymes, belonging to the CYP1, 2, and 3 families, are responsible for the biotransformation of most foreign substances inclu...
2. Factors such as age, gender, race, environment, and drug treatment may have considerable influence on the activity of these enzymes. 3. There are now well-established in vitro techniques for assessing the role of specific cytochrome P450 enzymes in the metabolism of drugs, as well as the...
Effects of dietary broccoli on human in vivo drug metabolizing enzymes: evaluation of caffeine, oestrone and chlorzoxazone metabolism. Carcinogenesis 1996;17:793–799. CAS Google Scholar Parker AC, Pritchard P, Preston T, Choonara I. Induction of CYP1A2 activity by carbamazepine in children using...