An estimated 80% of angioplasties performed in the USA each year now involve the use of a DES [1] . With the great success of these products has come numerous challenges, whether in the manufacturing and development of new DES or in designing clinical trials to evaluate their performance. ...
Since the introduction of insulin almost a century ago, more than 80 peptide drugs have reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis, multiple sclerosis, HIV infection and chronic pain. In this Perspective, we
An effective vaccine is urgently needed for malaria prevention36. In October 2021, RTS,S/AS01 became the first malaria vaccine to be recommended by WHO for children living in areas of moderate to highP. falciparumtransmission and is being rolled out in Ghana, Malawi and Kenya, with plans to...
Opioid use disorder (OUD) has become a serious leading health issue in the USA leading to addiction, disability, or death by overdose. Research has shown t... SC·S Wirkus - 《Bulletin of Mathematical Biology》 被引量: 0发表: 2022年 Factors Associated With the Presence of Co-occurring Pai...
Therapies initiated after July 2001 were excluded to allow for a follow-up period of at least three years and two months and to minimize right censoring data issues. The baseline analysis excluded chronic drugs for short-term use and included acute drugs for chronic use. The criteria for ...
Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs) how the US Food and Drug Administration (FDA) regulates dietary supplements within the framework of the Federal Food, Drug, and Cosmetic Act (FD&C Act)... RS Pawar,E Grundel - 《...
Fig. 6. Patterns in prevalence of substance use among adult 2015–2017 NSDUH participants by sexual identity and vulnerability. 4. Discussion Results from this study support previous research highlighting higher rates of substance use as well as mental health issues among SM. Although a clear associ...
[109]. Common adverse effects such as neurotoxicity, thrombocytopenia, cytokine release syndromes may be life threatening [110]. C-reactive protein along with various inflammatory cytokines are also elevated [111]. CAR-NK and CAR-M also exhibit several issues like limited proliferation capacity, ...
In this Review, we discuss strategies to select the best target antigens as well as suitable cytotoxic drugs; the design of optimized linkers; the discovery of bioorthogonal conjugation chemistries; and toxicity issues. The selection and engineering of antibodies for site-specific drug conjugation, ...
Anti-PEG antibodies in the clinic: current issues and beyond PEGylation. J. Control. Release 244, 184–193 (2016). CAS PubMed PubMed Central Google Scholar Baumann, A., Tuerck, D., Prabhu, S., Dickmann, L. & Sims, J. Pharmacokinetics, metabolism and distribution of PEGs and ...