The Impact of Drug Interactions on the Results of DAT-SPECT Imaging in a Specialty Movement Disorders Practice: A Retrospective Analysis of Outcomesdoi:10.1159/000540105PARKINSONIAN disordersPARKINSON'S diseaseMOVEMENT disordersDRUG interactionsBUPROPION...
The term pharmacomicrobiomics has been coined to describe the interactions between gut microbiota and drug response that can alter PK (i.e., changes in drug absorption, distribution, metabolism, excretion, and its plasma drug concentration dynamics) or PD (i.e., changes in drug targets or biolo...
Drug-drug interactions (DDIs) may trigger adverse drug reactions, which endanger the patients. DDI identification before making clinical medications is critical but bears a high cost in clinics. Computational approaches, including global model-based and local model based, are able to screen DDI candi...
occasions. This is a serious problem, for it can result in a normally effective dose of a drug being ineffective ortoxicin other circumstances. Many factors are known to contribute to this variability; some important ones are age, genetics, absorption,diseasestates, drug interactions, and drug ...
Therefore, identifying potential mistakes in large datasets and interpreting the results of AI models remains difficult. Researchers must understand drug properties, endpoint roles, effects, metrics and assessments, structure–exposure–activity relationships, drug interactions, and other related knowledge ...
A retrospective cross-sectional study design was conducted and serum AAG was determined, and potential drug-drug interactions were monitored in patients with severe obesity who underwent bariatric surgery. The drug classes most used were antidepressants, cardiovascular agents, and lipid-modifying agents, ...
and posttranscriptional regulatory mechanisms that result in inter-individual variations in pharmacotherapy; (2) current status and trends in assessing drug–drug interactions, especially interactions between drugs and herbs, between drugs and therapeutic biologics, and microbiota-mediated interactions; (3) ...
The purpose of the present experiment was to examine further the interactions between D1 and D2 receptors using drug discrimination (DD), a behavioral paradigm that is sensitive and selective for Dl and D2 agonist and antagonist activity. Two groups of male Sprague—Dawley rats ( N = 8/...
Drug-drug interactions (DDIs) may trigger adverse drug reactions, which endanger the patients. DDI identification before making clinical medications is critical but bears a high cost in clinics. Computational approaches, including global model-based and local model based, are able to screen DDI candi...
[145]. Various mechanisms and types of injury are involved, depending on the specific drug. However, a common risk factor appears to be polypharmacy, which increases the risk of drug–drug interactions and influences hepatic metabolism through various mechanisms, possibly increasing susceptibility to ...