A recent experimental study has suggested an increased toxicity of hydroxychloroquine in association with metformin in mice.The present study was undertaken to investigate the reality of this putative drug–drug interaction between hydroxychloroquine and metformin using pharmacovigilance data.Using VigiBase , ...
In summary, administration of the IBN/ SNAC formulation together with metformin did not lead to a significant increase in exposure to metformin. The study medication was well tolerated in healthy volunteers. 展开 关键词: Drug-drug interaction Ibandronate Metformin SNAC ...
In conclusion, DA-9801 moderately inhibited transport activity of OCT1 and OCT2 but did not show significant in vivo drug–drug interaction potential with metformin at its highest effective dose in rats. 展开 关键词: DA-9801 Metformin OCT (organic cation transporter Drug–drug interaction ...
There are several mechanisms by which drugs interact with other drugs, food, and other substances. An interaction can result when there is an increase or decrease in: the absorption of a drug into the body; distribution of the drug within the body; alterations made to the drug by the body...
simultaneously (e.g.,fungal infection, diabetes, hypercholesterolemia).Drug-drug interactionproblems which are not trivial and a major cause of hospital deaths (Montane׳et al., 2018) can have apharmacodynamicor apharmacokineticbasis. Often these drugs can interfere with the biotransformation of e...
The parent compound to metabolite ratios of warfarin, omeprazole and dextromethorphan were similar with and without administration of simeprevir, suggesting no relevant clinical interaction of simeprevir with CYP2C9, CYP2C19 and CYP2D6. Table 1 Effects of simeprevir on the pharmacokinetics (PK) of co...
Pharmacokinetic interaction between itraconazole and metformin in rats: competitive inhibition of metabolism of each drug by each other via hepatic and int... BACKGROUND AND PURPOSE Fungal infection is prevalent in patients with diabetes mellitus. Thus, we investigated whether a pharmacokinetic interaction...
Phase 1 and Pharmacokinetic Drug-Drug Interaction Study of Metformin, Losartan, and Linagliptin Coadministered With DW1029M in Healthy Volunteers. We investigated botanical drug-pharmaceutical drug interactions between DW1029M (a botanical extract of Morus alba linne root bark and Puerariae radix) and....
The drug classes most used were antidepressants, cardiovascular agents, and lipid-modifying agents, with a decrease in use after 12 months of surgery. Before surgery, it was found that more than half of the patients had at least one drug interaction in their therapeutic regimen. Of these, ...
Metformin ( dimethyl biguanide ) is a synthetic derivative of guanidine, isolated from the extracts of Galega officinalis , a plant with a prominent antidiabetic effect. Since its discovery more than 50 years ago, metformin represents a worldwide milestone in treatment of patients with type 2 ...