A flow induced autoimmune response and accelerated senescence of red blood cells in cardiovascular devices. Sci Rep. 2019;9:19443. Article ADS CAS PubMed PubMed Central Google Scholar Arakawa T, Kobayashi-Yurugi T, Alguel Y, Iwanari H, Hatae H, Iwata M, et al. Crystal structure of ...
Autoimmune diseases (AIDs) arise from a breakdown in immunological self-tolerance, wherein the adaptive immune system mistakenly attacks healthy cells, tissues and organs. AIDs impose excessive treatment costs and currently rely on non-specific and universal immunosuppression, which only offer symptomatic ...
In the latter (deriving from epilepsy surgery), we have shown that human tumour-necrosis-factor-related-apoptosis-inducing ligand, which is not toxic in mice (Walczak et al, 1999), induced lysis of non-transformed brain cells (Nitsch et al, 2000). Such highly relevant species differences ...
Furthermore, a gene expression analysis demonstrated that Box5 inhibited QUIN-induced expression of the pro-apoptotic genes BAD and BAX, while enhancing the expression of the anti-apoptotic genes Bcl-xL, BCL2, and BCLW. Subsequent analysis of cell signaling pathways implicated in this ...