50 Also a concomitantly occurring massive immune stimulation of T cells, as it occurs during generalized herpes or human immunodeficiency virus infections, or during exacerbations of autoimmune diseases, may be a cofactor for lowering the threshold of T-cell activation by drugs; such immune processes...
In patients with chronic myelogenous leukaemia, this term describes the progression of the disease to an acute advanced phase, evidenced by an increased number of immature white blood cells in the circulating blood. MULTIDRUG RESISTANCE Simultaneous resistance to several structurally unrelated drugs that ...
For example, during chemotherapy, P-gp may be an obstacle for drug exposure if the therapeutic drugs are P-gp substrates69. Besides its role in MDR induction, P-gp plays a critical role in pharmacokinetics, pharmacology and toxicology. Through pumping multiple drugs out of cells, P-gp ...
This could potentially accelerate time frames for compound discovery and optimization and enable more effective searches of chemical space. However, such approaches also raise considerable conceptual, technical and organizational challenges, as well as scepticism about the current hype around them. This ...
cells is the principal goal for cancer therapy. An important advantage of a delivery vector either viral or non-viral is the cumulative ability to penetrate the haphazardly arranged and immunosuppressive tumour microenvironment of solid tumours and or withstand antibody-mediated immune response. ...
We evaluated 16 patients with DRESS/DIHS for their clinical symptoms, laboratory data, copy numbers of HHV-6 and human cytomegalovirus (CMV) DNA in the peripheral blood mononuclear cells, serum cytokines and soluble interleukin-2 receptor (sIL-2R), as well as serum TARC. ...
TCM and NDDSs for the treatment of depression. With the help of new drug delivery strategies, traditional natural medicines can overcome the blood‒brain barrier and to provide greater advantages in the treatment of depression Full size image ...
cells [133]. Upregulation of Hedgehog signaling in CAF population leads to higher iCAF production leading to activation of Treg cells to cause immunosuppression [134]. Biglycan (BGN), a prognostic biomarker for predicting immunotherapy response is highly upregulated under immune-resistant conditions ...
It is noteworthy that T cells are one of the essential white blood cells existing in the immune system which exhibit a fundamental influence on adaptive immune responses. T cells are identified from other lymphocytes through the occurrence of T-cell receptors over their cell surfaces. T cells ...
& Lert, F. Isoniazid chemoprophylaxis of latent primary tuberculosis: in five trial centres in France from 1959 to 1969. Int. J. Epidemiol. 2, 153–160 (1973). Article CAS PubMed Google Scholar Menzies, D. et al. Four months of rifampin or nine months of isoniazid for latent ...