patient compliance For B: weak dose flexibility and more cost treatment and highly complex PK/PD For C: a profoundly different risk-benefit profile More difficult to adjust the ratio of activities at the different targets, but all these happen in the earlier stages of drug discovery process. An...
(DiscoveryofLeadcompound)新药开发的基本途径与方法之一 药物分子设计(Moleculardrugdesign)是指通过科学的构思和理性的策略,构建具有预期药理活性的新化学实体(newchemicalentities)的分子操作。 药物分子设计(Moleculardrugdesign) 是指通过科学的构思和理性的策略,构建具有预期药理活性的新化学实体(newchemicalentities)的分...
30、ncing biological research.It plays a key role in various stages of the drug discovery process including target identification computer screening of chemical compounds and pharmacogenomics Target SelectionLead DiscoveryMedicinal ChemistryIn Vitro StudiesIn Vivo StudiesClinical TrialsCellular & Geneti 31、...
•Newtechnology,•DiscoveryofDNA 1980s •CommercializationofDrugDiscovery •CombinatorialChemistry 1990s •Robotics•Automation Registration:MarketScenerio:•~$800Mspenttobringanewdrugtomarket.•$127BillionspentonPharmaR&Din2010•ShareofCROsinresearchoperationsis27%•WorldCROmarketis16.3B(Indian...
New Drug Development and Approval Process Contents Drug discovery and drug design Biological characterization Early formulation studies The investigational New Drug (IND) Application(研究性新药申请) The New Drug Application (NDA) The Federal Food, Drug, and Cosmetic Act,as regulated through Title 21 of...
Drug-discovery-and-development-药物发现和发展.ppt,Drug Discovery Development Introduction In the past most drugs have been discovered either by identifying the active ingredient from traditional remedies or by serendipitous discovery. But now we know dis
Itplaysakeyroleinvariousstagesofthedrugdiscoveryprocessincludingtargetidentificationcomputerscreeningofchemicalcompoundsandpharmacogenomics Bioinformatics Bioinformaticsmethodsareusedtotransformtherawsequenceintomeaningfulinformation eg genesandtheirencodedproteins andtocomparewholegenomes diseasevs not Cancomparetheentiregenomeof...
(部分)Processofdiscovery开发过程Establishobjectives确立设计目标Findleadcompound找到先导化合物Structure-ActivityRelationships构效关系Synthesizecompoundsandscreen合成化合物PiroxicamPiroxicam吡罗昔康Objectives目标 acidicbutnotacarboxylicacid有酸性但非羧酸 highlypotent强效 havealongplasmahalf-life(t½)血浆半衰期长 very...
第二十章 新药的研究和的设计DRUG DISCOVERY AND DESIGN-PPT文档资料 •第九章新药研究和设计•DrugDiscoveryandDesign 新药研究 一、有机药物的化学结构与药效关系二、新药发现的途径和新药设计三、前药原理 一、有机药物的化学结构与药效关系TheRelationBetweenChemicalStructureandActivityofOrganicDrugs 为什么要进行构...
Used in ? Drug discovery (hits) ? Lead optimization (hit to lead) ? Process chemistry and development Target Selection Lead Discovery Medicinal Chemistry In Vitro Studies In Vivo Studies Clinical Trials Library Development: Library Development SAR Studies In Silico Screening Chemical Synthesis Target ...