HistoryofDrugDiscovery:Pre1919 •HerbalDrugs•Serendiptiousdiscoveries 1970s •RiseofBiotechnology•UseofIT 1920s,30s •Vitamins•Vaccines 1960s •BreakthroughinEtiology 1940s •AntibioticEra•R&DBoostduetoWW2 1950s •Newtechnology,•DiscoveryofDNA 1980s •CommercializationofDrugDiscovery ...
Drug Discovery Development Introduction In the past most drugs have been discovered either by identifying the active ingredient from traditional remedies or by serendipitous discovery. But now we know diseases are controlled at molecular and physiological level. Also shape of an molecule at atomic level...
DrugDiscovery Development Introduction Inthepastmostdrugshavebeendiscoveredeitherbyidentifyingtheactiveingredientfromtraditionalremediesorbyserendipitousdiscovery Butnowweknowdiseasesarecontrolledatmolecularandphysiologicallevel Alsoshapeofanmoleculeatatomicleveliswellunderstood InformationofHumanGenome HistoryofDrugDiscovery ...
drug discovery and development-药物发现与发展.ppt,Introduction;History of Drug Discovery :;Registration:;~$800 M spent to bring a new drug to market. $127 Billion spent on Pharma RD in 2010 Share of CROs in research operations is 27% World CRO market is
12、ction Cellular and Genetic Targets Genomics Proteomics BioinformaticsLead Discovery Synthesis and Isolation Combinatorial Chemistry Assay development High-Throughput ScreeningMedicinal Chemistry Library Development SAR Studies In Silico Screening Chemical SynthesisIn Vitro Studies Drug Affinity and 13、Selectivit...
•第九章新药研究和设计•DrugDiscoveryandDesign 新药研究 一、有机药物的化学结构与药效关系二、新药发现的途径和新药设计三、前药原理 一、有机药物的化学结构与药效关系TheRelationBetweenChemicalStructureandActivityofOrganicDrugs 为什么要进行构效关系研究 不同化学结构的药物？不同的药理作用有细微差别的同一？不...
Drugdiscoveryanddevelopment Drugdiscoveryanddevelopment Thediscoveryphase Pre-discovery Gatherasmuchinformationaspossibleaboutthediseaseandtrytounderstanditsnature. Targetidentification Chooseamoleculeinthebodytotargetwithadrug;oftenaprotein. Targetvalidation
Drugs Discovery methods: – Random Screening – Molecular Manipulation – Molecular Designing – Drug Metabolites – Serendipity Target Selection ? Cellular and Genetic Targets ? Genomics Lead Discovery ? Synthesis and Isolation Medicinal Chemistry ? Library Development In Vitro Studies ? Drug Affinity and...
(DiscoveryofLeadcompound)新药开发的基本途径与方法之一 药物分子设计(Moleculardrugdesign)是指通过科学的构思和理性的策略,构建具有预期药理活性的新化学实体(newchemicalentities)的分子操作。 药物分子设计(Moleculardrugdesign) 是指通过科学的构思和理性的策略,构建具有预期药理活性的新化学实体(newchemicalentities)的分...
New Drug Development and Approval Process Contents Drug discovery and drug design Biological characterization Early formulation studies The investigational New Drug (IND) Application(研究性新药申请) The New Drug Application (NDA) The Federal Food, Drug, and Cosmetic Act,as regulated through Title 21 of...