Mimicking red blood cells to improve drug deliveryKatherine Harmon
Red blood cells: supercarriers for drugs, biologicals, and nanoparticles and inspiration for advanced delivery systems. Adv. Drug Deliv. Rev. 106, 88–103 (2016). Article CAS PubMed PubMed Central Google Scholar Song, W., Anselmo, A. C. & Huang, L. Nanotechnology intervention of the ...
The CNS is highly protected by physiological barriers, in particular, the blood–brain barrier and the blood–cerebrospinal fluid barrier, which limit access of most drugs. Biomaterials can be designed to bypass or traverse these barriers, enabling the controlled delivery of drugs into the CNS. In...
Many cell types, including red blood cells (RBCs), leukocytes, stem cells, platelets, dendritic cells, and even bacteria, have been leveraged for tissue-specific delivery of small molecules, large molecules, and even nanoparticles (Fliervoet and Mastrobattista, 2016). Cell-based targeting ...
Polymer nanoparticle as a delivery system for ribavirin: Do nanoparticle avoid uptake by Red Blood Cells? Yasmin Abo-zeid, Martin C. Garnett Article 101552 select article Preparation and characterization of dry powder containing sunitinib loaded PHBV nanoparticles for enhanced pulmonary delivery ...
(SDTM), which provides a harmonized structure for submission of clinical trial case list data to regulatory bodies, and it is required in both Japan and the US.13 The Standard for Exchange of Nonclinical Data (SEND) is closely related ...
句意:该药物增加了血液中的红细胞数量,提高了10%的摄氧量。A. absorbing吸收;B. enhancing提高;C. emerging显现;D. abusing滥用。根据“The drug increases the number of red cells in the blood”可知,药物增加了血液中的红细胞数量,由此可知,应该是提高了10%的摄氧量。故选B项。
and cells between the bloodstream and the CNS [14]. The highly limited barrier capacity of the BBB enables it to stringently regulate CNS homeostasis while simultaneously creating a hindrance to drug delivery to the CNS [15]. The BBB excludes 98% of small-molecule drugs and almost all large-...
by incorporating proteins into the RBCs that have an affinity for the drug and which do not readily diffuse out of the RBC. In other words, we have found that Red Blood Cells can be used as effective drug delivery systems when they contain proteins that do...
1. A drug delivery system comprising an active drug as a suspension of colloidal particles, each particle being coated with a material which provides a hydrophilic coat having a thickness of from 100 Å to 154 Å and a steric barrier to particle cell interaction. 2. A drug delivery syst...