Many researchers used a cell membrane coating to maintain the relative stability of nanoparticles during circulation in a complex blood environment. RBCm as camouflage is used to extend circulation and immune escape, while the NP core contributes to high drug loading. The coated nanoparticles include ...
The present invention relates to a composition comprising a drug that activates herpes virus entry mediator (HVEM). The present invention also relates to a composition comprising an agonist of HVEM. The present invention also relates to methods of stimulating, comprising administering to the mammal a...
公开/公告日期: 1998-09-15 申请(专利权)人: ADVANCED VIRAL RESEARCH CORP. 发明人: SZ Hirschman 摘要: The present invention discloses a method for treating anemia by stimulating red blood cells production by administering parenterally Product R, a peptide-nucleic acid preparation.收藏...
To test whether EpoR stimulation alters cell-cycle length in vivo, we used a mouse transgenic for histone H2B fused to a fluorescent timer protein (H2B-FT, Fig.2f), which fluoresces blue when first synthesized but matures over 1–2 h into a red fluorescent protein27. The ratio of blue...
Adeno-associated virus fNRBCs : Fetal nucleated red blood cells hiPSCs : Human-induced pluripotent stem cells References Wu H-H, Zhou Y, Tabata Y, Gao J-Q. Mesenchymal stem cell-based drug delivery strategy: from cells to biomimetic. J Control Release. 2019;294:102–13. CAS PubMed ...
Zhao and his co-authors decided to use that technique to see if they could deliver immune-system-stimulating chemicals to metastatic lung tumors rather than chemotherapy, which can damage lung tissue. They chose a chemokine, a small protein that attracts white blood cells, called CXCL10 as their...
stimulating leukocyte activation and recruitment via P2 receptor activation [52–54]. Extracellular ATP can also potentially exert important effects on the erythrocytes themselves, as erythrocyte P2 receptor activation on progenitor red blood cells can cause microparticle release, ROS formation and apoptosis...
Potential applications are not limited to an advanced RBC mimic: artificial cell-like systems could be imagined that take over other types of functions like those of T-Cells for cancer treatment, for maintaining blood-sugar levels and advanced biosensors for monitoring drug levels. Overall, the ...
and monocytes171. The cytoskeleton of bone marrow‐derived mesenchymal stromal cells (BM‐MSCs) was perturbed in addition to the upregulation of the expression hematopoietic-related genes such as granulocyte-macrophage colony-stimulating factor, tyrosine kinase-3 ligand and interleukin-3171. ...
The cause of PRCA is thought to be autoimmune, but viral infections and drug toxicities have also been implicated. As with aplastic anemia, a detailed mechanism of the pathophysiology remains uncertain, but support for autoimmune destruction of red cell precursors is favored based on patient response...