This naturalistic therapeutic drug monitoring (TDM) study was conducted in a transdiagnostic sample of children and adolescents treated with sertraline (n = 78; mean age, 14.22 ± 2.39; range, 7–18 years) within the prospective multicenter “TDM-VIGIL” project. Associations between dose, serum ...
1.50. For each group, we calculated odds ratios (ORs) for the association between the group classification and the effect oil ion channels/ion transport systems in kidney and car tissues. Results: Of 193 drug classes with relevant ADRs for renal disorders, 120 drug classes also had reports ...
Therapeutic drug monitoring of sertraline in children and adolescents: A naturalistic study with insights into the clinical response and treatment of obsessive-compulsive disorder. Compr. Psychiatry 2022, 115, 152301. [Google Scholar] [CrossRef] Peña, E.A.; Slate, E.H. Global validation of ...
Allelic or star (“*”) variants for drug-metabolizing enzymes represent combinations of co-segregating SNPs (haplotypes) and/or other polymorphisms that collectively determine the functional status of one inherited copy of a gene encoding a drug-metabolizing enzyme. From: Handbook of Clinical Neurolog...
“Omics” approaches can be used for identification or classification of toxic compounds or to generate mechanistic understanding of cellular processes underlying adverse outcomes to those compounds. Therefore, “omics” technologies are very suited to enhance preclinical safety assessment of DILI [200]. ...
DREAMwalk performs teleport operation while random walking by using semantic similarity as its guide (Fig.1a). The widely used Anatomical Therapeutic Chemical (ATC) classification and medical subject headings (MeSH) describe the semantic hierarchy of drugs and diseases, respectively (Supplementary Table1...
Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Therapeut 138, 103–141 (2013). 46. Baca, E., Garcia-Garcia, M. & Porras-Chavarino, A. Gender differences in treatment response to sertraline versus ...
Classification of drugs distinctly improved the sensitivity of the various pnf techniques like brisk stroking, quick stretch or vibration given directly on to the left of the. That is subsequently told that their doctors did not correlate with pain control is best remembered in vivid detail is an...
I have a patient taking the following drugs: aripiprazole, trazodone, sertraline, and simvastatin. Are there any potential drug-drug interactions with this combination of medications? Response from Joel W. Lamoure, RPh, BSP, FASCP Assistant Professor and Assistant CME Director, Schulich School of...
Depending on the disease stage and subtype classification, breast cancer treatment typically employs a multi-modal treatment approach using combinations of surgery, chemotherapy, endocrine therapy, and radiotherapy. The mainstay of therapy is, however, chemotherapy combined with surgery, particularly in ...