Finally, hypotension can develop when low-potency antipsychotics are used in combination with a variety of anesthetics, such as halothane, enflurane, and isoflurane. In addition, the low-potency antipsychotics (e.g., thioridazine) have quinidine-like effects on cardiac conduction and can prolong Q...
In the present study, we examined whether the extent of acylation of hepatic proteins in rats by halothane, enflurane, isoflurane, and desflurane correlated with reported relative rates of metabolism. After pretreatment with the P450 2E1 inducer isoniazid, five groups of 10 rats breathed 1.25 ...
Halogenated compounds (CC14, halothane, etc.) represent a major class of proteinbinding compounds. For this type of compound it has been postulated that the generation of C-centred radicals after halogen abstraction by the haem group of cytochromes or haemoglobin is the major mechanism involved in...
DILI can also result in chronic liver injury, a condition that manifests when DILI persists over an extended period because of the patient’s ongoing exposure to hepatotoxic medications.18 Specific drugs, such as amoxicillin/clavulanate, diclofenac, and halothane, are linked to this chronic form of...
KCB-328, in an infusion of 1 mg/kg/h, suppressed the occurrence of fatal ventricular fibrillation (VF) induced by coronary ligation and reperfusion under either halothane anesthesia (p < 0.05) or pentobarbital anesthesia (p < 0.05). Under the halothane anesthesia, KCB-328...
For DILI, the first reports linking HLA and genetic susceptibility involved the anesthetic halothane, which was used widely up to the 1980s and was also an important cause of idiosyncratic hepatitis up to that time. An association between the HLA class II serotype DR2 was reported by a study...
1. class: amino glycoside2. irreversible inhibition of 30S ribosome3. Synergistic with B-lactamsSE:1. nephrotoxic (high-output ATN)2. ototoxic (vestibular and hearing) Halothane (3) 1. probable main target: GABA-A receptorsSE:1. hepatitis 2. malignant hyperthermia3. arrhythmias4. MT: "Halo...
Beta blockers may negate the effect of dobutamine. ↑ risk of arrhythmias or hypertension with some anesthetics (cyclopropane, halothane ), MAO inhibitors, oxytocics, or tricyclic antidepressants. Route/Dosage Route/Dosage Route/Dosage IV (Adults and Children): 2.5–15 mcg/kg/min; titrate to res...
Target Empty CellDrug classGeneric nameAvailability CYP2E1 Disulfiram inhibition Anaesthetics Halothane Medical prescription Empty Cell Isoflurane Empty Cell Sevoflurane Empty Cell Methylxanthine Theophylline Medical prescription and OTC Empty Cell Analgesic Paracetamol Medical prescription and OTC CYP3A4 Inhibi...
(muscle) Enzyme D00542 Halothane hsa1571 cytochrome P450, family 2, subfamily E, polypeptide 1 D00437 Nifedipine hsa1559 cytochrome P450, family 2, subfamily C, polypeptide 9 D00528 Anhydrous caffeine hsa1549 cytochrome P450, family 2, subfamily A, polypeptide 7 D03670 Deferoxamine hsa1579 ...