Drugs acting on the cardiovascular system constituted the bulk of the prescriptions (25.87%), followed by gastrointestinal (GI) drugs (18.72%), vitamins and minerals (14.94%), and antibiotics (8.33%). Conclusion: There is polypharmacy in patients with renal impairment due to associated ...
1, 2, and 4) were prepared on the PVC tubes, which were then carefully connected with the right carotid artery and left external jugular vein of the rabbits (Fig.3e). After 2 h of ex
Because it is the fastest-acting opiate, heroin has a high potential for abuse. According to the American Society of Addiction Medicine (ASAM), an estimated 23 percent of heroin users become addicted to opioids. Physical dependence on the drug often causes long-term heroin users to experience ...
Application of the Nano-Drug Delivery System in Treatment of Cardiovascular Diseases. Cardiovascular diseases (CVDs) have become a serious threat to human life and health. Though many drugs acting via different mechanism of action are availa... Yudi,Deng,Xudong,... - 《Frontiers in Bioengineering...
When testing the safety pharmacology of a new product, the potential adverse pharmacodynamic effects need to be tested first on the three core organ systems: the CV system, the respiratory system, and the CNS. 3.Cardiovascular System Types of studies ...
The action of diazoxide (7-chloro-3-methyl-1,2,4-benzothiadiazine), a nondiuretic thiazide derivative, on the peripheral circulation and on left ventricular function was investigated. This drug was found to cause a marked reduction in the resistance to blood flow in the peripheral vasculature,...
Zero-shot drug repurposing involves predicting therapeutic candidates for diseases with limited or no treatment options (Fig.1b). Mathematically, the model inputs a queried drug–disease pair and outputs the likelihood of the drug acting on the disease. The gold standard labels for evaluating such...
For protein drugs acting on intracellular targets, a carrier is required to deliver the proteins into the cytosols to exert their bioactivity [166], [167], [168], [169], [170], [171]. How to efficiently attach the cargo proteins onto the polymer carriers is the major challenge [172], ...
In this simulation, the artery’s inlet velocity and outlet pressures are considered pulsatile based on the heart rate cycle shown in Fig. 1B. Forces acting on the drug carriers During blood circulation in a system containing drug-carrying nanoparticles and blood fluid, two types of volume and...
It should be noted, however, that no weight loss medication (or behavioral treatment89) has been shown to have a favorable effect on cardiovascular morbidity and mortality, and the Endocrinologic and Metabolic Drugs Advisory Committee has recommended to the FDA that all new medications reviewed for...