epinephrine-stimulated cAMP synthesisIn cells the stimulatory effects of epinephrine are mediated through the activation of a second messenger known as cAMP (cyclic adenosine monophosphate). The activation of this molecule results in the stimulation of cell-signaling pathways that act to increase heart ...
In April 2024, the DEA proposed to reschedule marijuana from Schedule I to III under the Controlled Substances Act (CSA). Schedule I drugs are defined as those that have a high potential for abuse and no currently accepted medical use in the United States....
Information describing how the product is defective and violates the FD&C Act or related statutes. address_2 results.address_2 string This is an .exact field. It has been indexed both as its exact string content, and also tokenized. product_quantity results.product_quantity string The amou...
The Gun-Free Schools Act (GFSA), which was Title XIV, Part F of the ESEA, was incorporated as part of SDFSCA because of its close relationship with the SDFSC program. This provision calls for each state receiving funds under the No Child Left Behind Act to have a law that requires LE...
A. et al. Tumor-associated macrophages act as a slow release reservoir of nano-therapeutic Pt(iv) pro-drug. Nat. Commun. 6, 8696 (2015). Article CAS Google Scholar Knudsen, K. B. et al. Differential toxicological response to positively and negatively charged nanoparticles in the rat ...
Since the introduction of insulin almost a century ago, more than 80 peptide drugs have reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis, multiple sclerosis, HIV infection and chronic pain. In this Perspective, we
In addition, cytotoxic drugs are also a difficult problem in ADC research, and conventional chemotherapy drugs are not powerful enough to act as ADC payloads [141]. In terms of ADC coupling methods, the non-site-specific coupling method is the method used in early ADC research; it offers ...
As anticoagulant response to UFH is unpredictable, UFH therapy is monitored mainly using the aPTT, although the activated clotting time (ACT) is used to monitor the higher UFH doses administered in PCI and cardiopulmonary bypass surgery [144]. The evidence behind the aPTT therapeutic range used ...
et al. Escherichia coli harboring mcr-1 and blaCTX-M on a novel IncF plasmid: first report of mcr-1 in the United States. Antimicrob. Agents Chemother. 60, 4420–4421 (2016). Article CAS PubMed PubMed Central Google Scholar Castanheira, M. et al. Detection of mcr-1 among ...
The two most prevalent factors associated with the act of reporting were the level of education (n = 3) and age (n = 3). Age did not reach consensus since 1 study [42] revealed that the younger population was more likely to report ADRs than older age groups, whereas 2 studie...