Part of the book series: Resistance to Targeted Anti-Cancer Therapeutics ((RTACT,volume 4)) 910 Accesses Abstract Drug resistance in the cancer cells is a leading cause of mortality during the cancer treatment. ABC transporters expressed in the cancer cells have been found to extrude anticancer...
Rollins. D.E.; von Bahr. C. Glaurnann, H.; Moideus. P. and Rane. A.: Actaminophen: Potentially toxic metabolite formed by human fetal and adult liver microsomes and isolated fetal liver cells. Science 205: 1414–1416 (1979). CAS Short, C.R.; Maines, M.D. and Westfall. B.A....
PICCS – Philippine Inventory of Chemicals and Chemical Substances TSCA – USToxic Substances Control Act Giftliste 1 (Swiss list of toxic substances, repealed in 2005)[22] Authorisation List TheEuropean Chemical Agency(ECHA) has published the REACH Authorisation List,[23]in an effort to tighten ...
Since the introduction of insulin almost a century ago, more than 80 peptide drugs have reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis, multiple sclerosis, HIV infection and chronic pain. In this Perspective, we summarize key trends in peptide drug disco...
N Engl J Med 1976;2951482- 1483PubMedGoogle Scholar 95. Hansen JMSiersboek-Nielsen KSkovsted L Carbamazepine-induced acceleration of diphenylhydantoin and warfarin metabolism in man. Clin Pharmacol Ther 1971;12539- 543PubMedGoogle Scholar 96. Breckenridge AOrme M Clinical implications of enzyme...
This systematic review and meta-analysis outlines the evidence for nonpharmacological interventions for postoperative pain management after total knee
As anticoagulant response to UFH is unpredictable, UFH therapy is monitored mainly using the aPTT, although the activated clotting time (ACT) is used to monitor the higher UFH doses administered in PCI and cardiopulmonary bypass surgery [144]. The evidence behind the aPTT therapeutic range used ...
Maladie des spasmes en flexion: troubles cliniques et m¨¦taboliques observ¨¦s en cours de traitement par le tetracosactide zinc.Pediatrie, 31 (1976) 33–48. PubMed CAS Google Scholar Dreifuss, E, Farwell, J., Holmes, G., Joseph, C., Lockman, L., Madsen, J.A., Minarc...
disorders. From the microarray studies performed on human postmortem brain samples from schizophrenics, the systems most implicated to be dysfunctional are synaptic machinery, oligodendrocyte/myelin function, and mitochondrial/ubiquitin metabolism. Drugs may act directly or indirectly to compensate for ...
This is also the case for suramin (7), but we have shown that the two drugs can act in synergy to inhibit hPIV-3 infection in vitro. As a result, we showed that the dose of both drugs can be significantly reduced to reach high levels of inhibition, as compared to the individual ...