DPYD genetic polymorphisms in non-European patients with severe fluoropyrimidine-related toxicity: a systematic reviewGenetics researchRisk factorsPre-treatment DPYD screening is mandated in the UK and EU to reduce the risk of severe and potentially fatal fluoropyrimidine-related toxicity. Four DPYD gene ...
[2] Atasilp C, Biswas M, et, al. Association of UGT1A1*6, UGT1A1*28, or ABCC2 c.3972C>T genetic polymorphisms with irinotecan-induced toxicity in Asian cancer patients: Meta-analysis. Clin Transl Sci. 2022 Jul;15(...
and Liaoning Cashmere goat. And count the degree of correlation between it and the kidding performance of Yunshang Black goats (litter size, litter weight at birth and litter weight at weaning). Population genetic analysis showed that the DPYD ...
J Hum Genet (2007) 52:804–819 DOI 10.1007/s10038-007-0186-6 ORIGINAL ARTICLE Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences Keiko Maekawa Æ Mayumi Saeki Æ Yoshiro Saito Æ Shogo Ozawa Æ ...
As such, the variants analyzed, test design, interpretation, and clinical use are different; however, some laboratories may offer a single DPYD genetic test for both diagnostic and pharmacogenomic indications. DPYD Variants and Haplotypes Some DPYD variants were assigned star (∗) allele numbers ...
*Tempus Merlin was developed and is performed by Skyline Dx as a reference laboratory xT CDx is a qualitative Next Generation Sequencing (NGS)-based in vitro diagnostic device intended for use in the detection of substitutions (single nucleotide variants (SNVs) and multi-nucleotide variants (MNVs...
Severe toxicity to 5-fluorouracil (5-FU) based chemotherapy in gastrointestinal cancer has been associated with constitutional genetic alterations of the dihydropyrimidine dehydrogenase gene (DPYD). Methods In this study, we evaluated DPYD promoter methylation through quantitative methylation-specific PCR and...
[283]Song G., Cui Z., Mob Genet Elements, Novel strategies for gene trapping and insertional mutagenesis mediated by Sleeping Beauty transposon, Mobile Genetic Elements, 2013, 3, e26499 10.4161/mge.26499Search in Google Scholar PubMed PubMed Central [284]Ranzani M., Annunziato S., Adams ...
The analysis of genetic variations of drug-metabolizing enzymes is thought to be a useful tool in predicting individuals being at risk for adverse drug reactions [25]. The enzyme DPD plays a critical role in the catabolism of the anticancer agent 5-FU and is involved in severe life-...
Development of rapid assays to detect mutations in the DPYD gene makes it possible to carry out a genetic screening prior to the start of chemotherapy containing 5-FU. However, it is impor- tant to identify those mutations that result in a defect DPD protein. So far, 19 molecular defects ...