binding domains [16]. Therefore, the functional domains responsible for currently discovered function of DPP-4 are all located in the extracellular portion and the functions of intracellular domain of DPP-4 remain elusive. The structures of DPP-4 and GLP-1 are illustrated in Fig.1. Fig. 1 Mo...
It has been shown that GLP-1 signaling is also active in the cardiovascular system, where it may exert beneficial effects. However, DPP-4 has several non-incretin substrates, and its immunomodulatory activity is known from decades. DPP-4 physiologically cleaves cytokines, chemokines and ...
Second, I examined the effect of sitagliptin and GLP-1 receptor agonist exendin 4 on EDRs in hypertension. The major novel findings of this part include: (1) two-week oral administration of sitagliptin to SHRs lowered systolic blood pressure and improved renal blood flow in vivo; (2) ...
DPP-4 inhibition enhanced renal tubular and myocardial GLP-1 receptor expression decreased in CKD with myocardial infarction Seung Jung Kim, Soon Kil Kwon, Hye-Young Kim, Sun Moon Kim, Jang-Whan Bae & Joong-Kook Choi BMC Nephrology volume 20, Article number: 75 (2019) Cite this ar...
Dipeptidyl peptidase IV (DPP-IV; E.C. 3.4.14.5), a serine protease that degrades the incretin hormones GLP-1 and GIP, is now a validated target for the treatment of type 2 diabetes. Dipeptide boronic acids, among the first, and still among the most potent DPP-IV inhibitors known, suffe...
DPP-4 is widely distributed throughout most tissues of the body and acts as a plasma membrane enzyme34. It regulates postprandial glucose by rapidly inactivating GLP-1 and GIP35. Therefore, DPP4 inhibitors stimulate insulin secretion in a glucose-dependent manner and reduce glucagon secretion from ...
Moreover, one study compared SGLT-2 inhibitors with other glucose lowering drugs which also included DPP-4 inhibitors together with other glucose lowering drugs. Moreover, study Chang2017 compared DPP-4 inhibitors versus non-DPP-4 inhibitors which included SGLT-2 inhibitors as well as other ...
2010; 1(1/2): 8-23肠促胰素在血糖稳态中的作用肠促胰素(GIP和GLP-1)持续分泌肠促胰素释放增加食物摄取胃肠道DPP-4酶迅速降解肠促胰素肠促胰素的作用+-胰岛β细胞α细胞胰岛素释放增加胰高血糖素降低肌肉摄取葡萄糖增加肝糖输出减少Muscle肌肉肝脏Liver血糖稳态DPP=dipeptidyl peptidase; GLP=glucagon-like peptide...
Inhibition of Dipeptidyl Peptidase IV Improves Metabolic Control Over a 4-Week Study Period in Type 2 Diabetes OBJECTIVE -- Glucagon-like peptide-l (GLP-1) has been proposed as a new treatment modality for type 2 diabetes. To circumvent the drawback of the short hal... A Bo,E Simonsson,...
Inhibition of Dipeptidyl Peptidase IV Improves Metabolic Control Over a 4-Week Study Period in Type 2 Diabetes OBJECTIVE -- Glucagon-like peptide-l (GLP-1) has been proposed as a new treatment modality for type 2 diabetes. To circumvent the drawback of the short hal... A Bo,E Simonsson,...