Double stranded RNA binding domains There is currently one commonprotein domainthat is responsible for bindingRNAduplexes. Thisdouble stranded RNAbinding motif (dsRBM) is a small ∼70amino acidglobular domain with an α1β1β2β3α2secondary structure. It folds to form a three-stra...
Double-stranded RNA-binding domain (dsRBD) is a protein domain with mixed αβ topology that binds to double-stranded RNA (dsRNA). End-recognition domains recognize features like the presence or absence of phosphates, and the number of phosphates present on the 3′- and 5′-ends of double-...
B. The double-stranded-RNA-binding motif: interference and much more. Nat. Rev. Mol. Cell Biol. 5, 1013–1023 (2004). Article CAS PubMed Google Scholar Gleghorn, M. L. & Maquat, L. E. ‘Black sheep’ that don’t leave the double-stranded RNA-binding domain fold. Trends Biochem...
The interferon-induced, double-stranded RNA (dsRNA)-dependent protein kinase, PKR, is an inhibitor of translation and has antiviral, antiproliferative, and antitumor properties. Previously, thedsRNA bindingdomain had been located within the N-terminal region of PKR and subsequently shown to include tw...
The double-stranded RNA binding domain (dsRBD) is a small protein domain of 65–70 amino acids adopting an αβββα fold, whose central property is to bi... G Masliah,P Barraud,HT Allain - 《Cellular & Molecular Life Sciences》 被引量: 0发表: 2013年 RNA recognition by double-strande...
Z-α-DOMAIN A protein domain that binds left-handed Z-form DNA, which is believed to occur transiently in the cell during gene transcription. About this article Cite this article Tian, B., Bevilacqua, P., Diegelman-Parente, A.et al.The double-stranded-RNA-binding motif: interference and ...
4) dsRNA-binding domain 双链RNA结合蛋白5) Amplisen 人工合成错位双链RNA6) double-stranded chain 双链结构补充资料:聚合物链结构(见高分子链结构) 聚合物链结构(见高分子链结构) chain structure of polymer 聚合物链结构Chain strueture of pol卿er见高分子链结构。 说明:补充资料仅用于学习参考,请勿...
RNA recognition by double-stranded RNA binding domains: A matter of shape and sequence. Cell. Mol. Life Sci. 2013, 70, 1875–1895. [CrossRef] [PubMed] 86. Stefl, R.; Oberstrass, F.C.; Hood, J.L.; Jourdan, M.; Zimmermann, M.; Skrisovska, L.; Maris, C.; Peng, L.; ...
Biological & Pharmaceutical BulletinImproving the stability ofshort hairpin RNA against fetal bovine serum using the third double-stranded RNA-binding domain ... KAWAGUCHI,Yasuhisa,DANJO,... - 《Biological & Pharmaceutical Bulletin》 被引量: 10发表: 2009年 Prospects of using interferon inducers of th...
Site-directed mutagenesis confirmed that deletion of the VP3 dsRNA binding domain restored IFN-β expression. Our data demonstrate that VP3 inhibits antiviral innate immunity by blocking binding of viral genomic dsRNA to MDA5.MDA5, a known pattern recognition receptor and cytoplasmic viral RNA ...