Dofetilide: what role in the treatment of ventricular tachyarrhythmias? Background: The effect of withdrawal of digoxin on left ventricular function inpatients with a history of idiopathic dilated cardiomyopathy (IDCNI) followi... N Saoudi,Rinaldi J.P,K Yaici,... - 《European Heart Journal》...
Double-blind, placebo-controlled study of the efficacy of flosequinan in patients with chronic heart failure receiving digoxin and diuretic drugs were randomly assigned (double-blind) to the addition of flosequinan (100 mg once daily, n = 93) or placebo (n......
cardiomyocytes transmembrane potential and the Na鈥揔exchange on the cell surface of the action potential phase 4 caused by the poisoning dose of digoxin, leading to the oscillation of adsorbed ions on the cell surface and the incomplete channel structure, which were the mechanism of cardiac ...
The results suggest that digoxin is ineffective at the recommended dosage. Procaineamide was effective in controlling some arrhythmias, but disopyramide was the most effective agent studied. All these patients showed a mixture of arrhythmias, and also had a lot of ectopic activity. Arrhythmic ...
Digoxin 127 (52.05) 136 (55.06) 263 (53.56) NYHA functional class I 0 0 0 II 52.46 53.44 52.95 III 41.80 41.70 41.75 IV 5.74 4.86 5.3 Echocardiography measurements LVEF, % 31.85 ± 6.41 31.86 ± 6.46 31.85 ± 6.43 LVED, mm 66.54 ± 10.13 66.63 ± 10.67 66.59 ± 10.39 Laboratory me...
Digoxin Monitor serum digoxin levels Increased digoxin blood levels can occur with concomitant sulfamethoxazole and trimethoprim therapy, especially in elderly patients. Indomethacin Avoid concurrent use Increased sulfamethoxazole blood levels may occur in patients who are also receiving indomethacin. Pyrim...
This randomised, placebo-controlled, double-blinded phase IIb clinical trial compares the improvement on ventricular function (measured by the changes on the ejection fraction) of patients receiving the conventional treatment for DC in combination with a single dose of an intracoronary infusion of BMM...
Increased digoxin blood levels can occur with concomitant sulfamethoxazole and trimethoprim therapy, especially in elderly patients. Serum digoxin levels should be monitored. Increased sulfamethoxazole blood levels may occur in patients who are also receiving indomethacin. ...
the upper limit of normal, dialysis, or a creatinine level >1.5 mg/dl, treatment with a biologic agent or with cyclophosphamide within 3 months of screening, treatment with rituximab within 12 months of screening, pregnancy, lactation, treatment with digoxin, or treatment with teriparatide (Forteo...
Cawello W, Mueller-Voessing C, Andreas JO. Effect of lacosamide on the steady-state pharmacokinetics of digoxin: results from a phase I, multiple-dose, double-blind, randomised, placebo-controlled, crossover trial. Clin Drug Investig. 2014;34:327–34....