Fig. 2. Illustration of a dopaminergic synapse. DA (blue spheres) is packaged into vesicles in the presynaptic terminal via VMAT. Released DA stimulates post-synaptic D1-like and D2-like G-protein coupled receptors. Released DA is cleared from the synaptic cleft via the DAT or degraded via...
Inves- tigating the dopaminergic synapse in vivo. I. Molecular imaging studies in humans. Rev Neurosci 2007;18:439e72.Nikolaus S, Antke C, Kley K, Poeppel TD, Hautzel H, Schmidt D, Muller HW. Investigating the dopaminergic synapse in vivo. I. Molecular imaging studies in humans. ...
Prenatal ethanol exposure impairs lesion-induced plasticity in a dopaminergic synapse after maturity This study examined the consequences of alcohol (ethanol) exposure during fetal life on lesion-induced dopaminergic synapse responsiveness (plasticity) in ... Z Gottesfeld,Garcia, C.J.,Lingham, R.B....
Since mitochondria play a critical role in proper synapse signaling and PD is directly linked to mitochondria dysfunction, we wanted to study altered properties of DA synaptic mitochondria in the early stage of PD. With triple staining of anti- TH, a fixable synaptic marker FM1-43fx and a ...
Geula C, Slevin JT (1989): Substantia nigra 6-hydroxydopamine lesions alter dopaminergic synaptic markers in the nucleus basalis magnocellularis and striatum of rats. Synapse 4:248–253Geula C. and Slevin J. T. (1989) Substantia nigra 6-hydroxydopamine lesions alter dopaminergic synaptic markers ...
1.6 mM in the NAc [43]) that might function rather selectively on dopamine receptors localized within or around the synapse (Figure 3). Importantly, phasic release of dopamine is expected to affect a relatively restricted number of postsynaptic neurons within the striatum, because diffusion of ...
(DAT), which is the main clearance mechanism of DA at the synapse (Hyman et al, 2006). Ethanol can act directly on receptors and ion channels located on VTA DA neurons to increase cellular firing while simultaneously modulating GABAergic inputs onto VTA DA neurons (Brodie et al, 1990;...
Dopaminergic modulation at the olfactory nerve synapse - ScienceDirect Dopamine can change the membrane potential, regulate cyclic nucleotides, and modulate transmitter release in central neurons. In the olfactory bulb (OB), t... DA Berkowicz,PQ Trombley - 《Brain Research》 被引量: 265发表: ...
Synapse 50, 200–205 (2003). CAS PubMed Google Scholar Melis, M., Camarini, R., Ungless, M. A. & Bonci, A. Long-lasting potentiation of GABAergic synapses in dopamine neurons after a single in vivo ethanol exposure. J. Neurosci. 22, 2074–2082 (2002). CAS PubMed PubMed Central...
Amphetamines increase synaptic DA by causing its release into the synapse and both amphetamines and cocaine potently inhibit the DA reuptake transporter. Show moreView chapter Review article The many facets of dopamine: Toward an integrative theory of the role of dopamine in managing the body's ener...