Fig. 1: Workflow of the selection and analysis of dopamine and serotonin gene sets. AStrategy for the selection of the serotonin (SERT) and dopamine (DA) gene sets using Gene Ontology and KEGG’s pathways for the wide sets and manual curation for the core sets. All genes of the core ge...
using the terms "dopamine" or "serotonin" as keywords, and only those pathways more tightly related to neurotrans- mitters' function were kept: "dopaminergic synapse" (hsa04728) and "tyrosine metabolism" (hsa00350), and "serotonergic synapse" (hsa04726) and "tryptophan metabolism" (hsa00380)...
Transcriptome sequencing results corroborated that genes differentially expressed due to UCB-Exos were primarily enriched in the neuroactive ligand-receptor interaction, Dopaminergic synapse, and MAPK signaling pathway. We also observed that UCB-Exos significantly inhibited the hyperphosphorylation of the MAPK ...
Enriched KEGG dopaminergic synapse pathway following perinatal nicotine exposure in DA neurons. KEGG’s DAergic synapse pathway describes the release of the neurotransmitter DA from the presynaptic (orange) to the postsynaptic (pink) neuron. miR-30b-5p (dark blue) was predicted to target Scn1a, a...
How did the expression of wild-type parkin affect oxidized dopamine levels in parkin mutant neurons? How does neuronal depolarization influence the activation of parkin at the synapse? How does impaired ubiquitination of Synaptojanin 1 (SYNJ1) in mutant parkin neurons affect synaptic vesicle recycling...
The axonal guidance KEGG pathway was significantly enriched among the upregulated genes following both treatment groups. Additionally, the glutamatergic synapse KEGG pathway was enriched among the significantly differentially expressed up and downregulated genes following both treatment groups. This information ...