Drugs that disrupt the storage of noradrenaline, like Rawolfia alkaloids and tetrabenazine, also disrupt DA storage complexes, and many of the behavioural sequelae of their administration may be related to the action on DA storage rather than on that of noradrenaline. Dopamine release DA is ...
For example, nonassociative changes in dopamine neurotransmission may set thresholds for the effects of drugs on associative learning. Animals that have high general behavioral reactivity (indicated by a large locomotor response to a novel environment) appear to release larger amounts of dopamine into...
All rights reserved 0893-133X/16 www.neuropsychopharmacology.org Relative Timing Between Kappa Opioid Receptor Activation and Cocaine Determines the Impact on Reward and Dopamine Release Elena H Chartoff*,1, Shayla R Ebner2, Angela Sparrow1, David Potter1, Phillip M Baker3, Michael E Ragozzino2 ...
Heterozygous mice that express Cre-recombinase under the dopamine transporter promoter (DAT-Cre knock in mice, or KI) are widely used for targeting midbrain dopamine neurons, under the assumption that their constitutive physiology is not affected. We rep
Elena H. ChartoffspPsychopharmacologyEbner SR, Roitman MF, Potter DN, Rachlin AB, Chartoff EH (2010) Depressive-like effects of the kappa opioid receptor agonist salvinorin A are associated with decreased phasic dopamine release in the nucleus accumbens. Psychopharmacology (Berl) 210:241–252. :...
Behavioral stressors increase addiction risk in humans and increase the rewarding valence of drugs of abuse including cocaine, nicotine and ethanol in animal models. Prior studies have established that this potentiation of drug reward was mediated by stress-induced release of the endogenous dynorphin op...
A The force histograms of DENV-D2R interaction pre-treated with the drugs (gray) show a particular depletion of DENV-D2R binding forces in the untreated experiments (white), suggesting that the drugs prevented specific DENV-D2R binding interaction. B The box chart (25th and 75th percentile, ...
These drugs were dissolved in ACSF alone. Data analysis A single unit spike was discriminated on the basis of the height and width of each unit from a multiple unit recording by applying cluster analysis methods with the software program "Chart and Spike Histogram" (AD Instruments Co., Tokyo,...
The auditory striatum, the tail portion of dorsal striatum in basal ganglia, is implicated in perceptual decision-making, transforming auditory stimuli to action outcomes. Despite its known connections to diverse neurological conditions, the dopaminergic
nucleus accumbens INTRODUCTION Negative affective signs and symptoms, including anxiety, irritability, anhedonia, and dysphoria, are common to withdrawal from all classes of abused drugs, are manifested after the very first exposure to a drug, and increase in intensity with repeated exposures (Koob an...