Dopamine is well recognized as a neurotransmitter in the brain, and regulates critical functions in a variety of peripheral systems. Growing research has also shown that dopamine acts as an important regulator of immune function. Many immune cells express dopamine receptors and other dopamine related ...
Neuropsychopharmacology 995 Kappa opioid receptor interactions with cocaine EH Chartoff et al 996 Figure 3 Relative timing of salvA pretreatment to cocaine challenge determines whether KOR activation increases or decreases cocaine-potentiated dopamine release in the nucleus accumbens (NAc) core measured ...
Insert: comparison of corresponding regression slopes for individual sessions. Bars represent the mean and dots represent the individual sessions (***p = 0.0005, two-sided Wilcoxon rank-sum test). f Left, schematic for bilateral optogenetic inhibition of the D2-MSNs. Right, psychometric ...
In the case of a general loss of preference, we would predict that the preference indices on day 4 would no longer differ significantly from 0.5 (the string pull distribution expected by chance; see Figure 1E for comparison). Instead, we find that the day 4 preference indices were ...
B The box chart (25th and 75th percentile, mean, and standard deviation) shows that the DENV-D2R binding force did not depend on the drug concentration. The binding forces remained at 50–60 pN (mean) without significant differences; “NS” indicates not significant (p > 0.05 by the ...
5. Kinetic comparison of normalized dopamine responses. (A) Scaled responses to flash photolysis (2.5 ms, 1.8 mW) of CyHQ-O-DA (50 μM), electrically stimulated dopamine IPSC (single stimulation), and dopamine iontophoresis (1 M dopamine, 4 nA backing current, 10 ms of a 100 nA ejection...
Development of R-GenGAR-DA1.1, which showed a positive response to dopamine (DA).aStrategy to develop R-GenGAR-DA1.0. Left panels show a schematic illustration of human DRD1 and the red fluorescent protein ‘cpmApple’ insertion site. Right panels show screening flow chart. Linker sequences ...
Jackson J. Cone,Elena H. Chartoff,David N. Potter,Stephanie R. Ebner,Mitchell F. Roitman Full-TextCite this paperAdd to My Lib Abstract: The development of diet-induced obesity (DIO) can potently alter multiple aspects of dopamine signaling, including dopamine transporter (DAT) expression and...
Female KIs not only showed categorically different behavioral phenotypes in comparison to males, but also had a disproportionate reduction in DAT expression, given that female WTs showed higher DAT expression than male WTs, particularly in the NAcc core. It is likely that this is linked to the ...
Data are summarized in (panel c) (comparison to the iontophoresis data presented in Figure 2, ANOVA followed by Dunnett's post hoc, *P ¼ 0.024 for staurosporine). dopamine current ( + 16±15%, n ¼ 11, P ¼ 0.02); however, CRF produced a further increase that was not different...