Dopamine dysregulation in the brain network of de- cision-making: Can this explain the psychopathology of schizofrenia? In: Kasper S, Papadimitriou GN, eds. Schizophrenia. Biopsychosocial approaches and current challenges. 2nd edition. Informa Healthcare: London 2009; 386....
The present chapter reviews the abnormality of the decision-making network in schizophrenia to suggest that this disorder is associated with pervasive abnormalities in this network and its dopamine regulation. The review focuses on the dACC, basal ganglia, and thalamus. We then introduce a model ...
These findings support the dopamine hypothesis of schizophrenia ( Matthysse, 1973 , 1974 ; Matthysse and Lipinski, 1975 ), which may be succinctly stated as follows: "certain (but unknown dopaminergic pathways are overactive in schizophrenia"....
Schizophrenia.This severe but treatable psychiatric disorder causeshallucinations(seeing things that aren’t real) anddelusions(firmly believing in untrue ideas). Other symptoms include disorganized thoughts and unusual body movements. A dopamine imbalance along different pathways in the brain causes these ...
schizophrenia. Dopamine: metabolism, dopaminergic pathways, behavioral, and physiological functions After the synthesis, DA is incorporated into synaptic vesicles by the vesicular monoamine transporter-2 (VMAT2) and stored in the vesicles in catecholaminergic neurons [25]. Following an action potential to...
Global Expression Studies of Schizophrenic Brain: A Meta-Analysis Study Linking Neurological Immune System with Psychological Disorders. Schizophrenia, a psychological disorder with enormous societal impact, is a result of abnormalities in gene expression and dysregulation of the immune resp... Sajjad,Karim...
Direct and indirect interactions of the dopamine D3 receptor with glutamate pathways: implications for the treatment of schizophrenia 来自 Springer 喜欢 0 阅读量: 24 作者:P Sokoloff,L Leriche,J Diaz,J Louvel,R Pumain 摘要: This article, based on original data as well as on previously ...
Our knowledge of the neurobiology of schizophrenia, while still rudimentary, has advanced considerably in recent years. However, these findings have not translated to better treatments for those with schizophrenia. The three primary symptom groups, positive, cognitive and negative (Box1), have been as...
Schizophrenia is a most disabling psychiatric disorder characterized by a myriad of symptoms. While the delusions and hallucinations are the most iconic symptoms of schizophrenia, patients also exhibit negative and cognitive symptoms. It is thought that these symptoms arise, at least in part, through ...
The dopamine hypothesis of schizophrenia and the emphasis on other neurotransmitters, most notably norepinephirne, serotonin, and acetylcholine, in the pat