or effects restricted to post-learning decision-making25,26. Interpretation of D2 receptor antagonist effects are complicated by the fact that lower dosages predominantly affect presynaptic D2 autoreceptors27, which, via an inhibition of negative feedback27, likely increases (rather than decreases...
Bipolar affective disorder is a common neuropsychiatric disorder. Although its neurobiological underpinnings are incompletely understood, the dopamine hypothesis has been a key theory of the pathophysiology of both manic and depressive phases of the illness for over four decades. The increased use of anti...
This should provide a good test of the hypothesis of an association of DRD4 alleles with novelty seeking, unless the DRD4*7R allele represents a large gain of function, that is, unless the difference between the DRD4*7R allele and the DRD4*4R allele (for example) is quantitatively greater ...
‘wanting’ for food reward, a potential hedonic suppression that is opposite from what the hedonia hypothesis should predict (dopamine-mediated suppression of ‘liking’ appears to be independent of incentive salience attribution; the mechanism of hedonic suppression is not fully understood but might ...
Simply put, standard RL algorithms compute reward prediction on observable states, but under state uncer- tainty reward predictions should normatively be computed on belief states, which correspond to the probability of being in a given state. This leads to the hypothesis that dopamine activity ...
cell death and causes functional deficits. Effectively blocking these effects of inflammation could, therefore, reduce both neuronal and functional decline. To test this hypothesis, we inhibited vascular adhesion protein 1 (VAP-1), a membrane-bound protein expressed on the endothelial cell surface, th...
A prediction of this hypothesis is that, following cue onset in the 90%-rewarded task, PL neurons show sustained activation that decreases as time within the trial elapses (similar to the colored bars for task 2 in Figure 7B), whereas IL neurons show ramping that increases as time elapses...
These suggestions of opponency were leveraged in an early attempt (Daw et al, 2002) to extend the relatively more detailed computational understanding of DA into a hypothesis about serotonergic function. This model posited that 5-HT might serve as simply a mirror image to the dopaminergic reward...
Genotypic Variation in Receptor Expression and Decision Making The hypothesis that D1 and D2 receptors play dissociable roles in the reinforcement learning that underlies value- based decision-making raises the important question as to whether individual differences in their expression might influence ...
Although he has thought about writing a popular-press book, he's not sure he really wants to go to the public and "debunk" the dopamine hypothesis of pleasure and reward. But if he ever does, one thing is for sure. "I can sum up all this work with one phrase, which would make a...