Tau-5, which plays a key role in transactivation by the splice variants associated with CRPC, harbors the binding site of EPI-001 (ref. 23), a small-molecular inhibitor of the AR AD discovered by phenotypic screening24, a derivative of which is being investigated in clinical trials for ...
While TRPV1 is expressed in neuronal and non-neuronal tissues, its role in neuronal tissues has garnered significant interest7. For example, in group C unmyelinated nerve tissue of the peripheral nervous system, TRPV1 is integral to nociception (pain)8,9. Consequentially, there is interest in...
The weaker of the (Ca2+)4-CaM-binding sites was known via electrophysiology to have a role in long-term inactivation of the channel but not known to bind CaM. FGF12A binding to a complex of CaM associated with a fragment of the NaV1.2 CTD increased the Ca2+-binding affinity of both ...
However, in contrast to its role in activation of the K10 promoter, this effect is independent of DNA binding. The POU domain, which is normally responsible for DNA binding, is the primary mediator of the repression. The repression maps to the proximal promoter region of the K14 gene. This...
Induction of metallothionein I by arsenic via metal-activated transcription factor 1: critical role of C-terminal cysteine residues in arsenic sensing Metal-activated transcription factor 1 (MTF1) mediates the induction of metallothioneins I and II by zinc and stress signals. The mechanism of MTF1 ...
Role of graphene defects in corrosion of graphene-coated Cu(111) surface Protection of Cu(111) surface by chemical vapor deposition graphene coating is investigated. The X-ray photoemission spectroscopy results do not reveal any... I Wlasny,P Dabrowski,M Rogala,... - 《Applied Physics Letters...
The phosphatidylinositol-4, 5-bisphosphate 3-kinase (PI3K)-Akt signaling pathway plays an important role in breast cancer development. As the most critical signal molecule in this pathway, p-Akt has attracted considerable attention as a therapeutic target [11]. p-Akt is associated with resistance...
13. A soluble form of the RTP that is not associated with the capsid plays a role in phloem limitation and movement within the plant host13,14. The readthrough domain itself can be subdivided into a globular N-terminal portion (NRTD) and an unstructured C-terminal portion (CRTD) that ...
Despite these differences, we observed that both DBD and TAD mutant forms of p53 interact with the EGFR. The EGFR-AKT-PI3K-mTOR axis plays a central role in cellular growth and metabolism and is frequently altered in cancer. We therefore investigated whether TAD versus DBD forms of mutant p53...
The ratios suggest purifying selection eliminated mutants in the kinase domain but not the LRR domain. The relative lack of amino acid sequence variance per nucleotide change may be associated with the role of the kinase domain in the signaling function. Appropriate message transduction imposes severe...