Literature to date focuses on humans; although some references to molecular mechanisms regulating cancer cells metabolism derive from studies on experimental tumours and cell biology. Literature shows that some tumours, especially those of the brain and head/neck and lung, are glucose-dependent, and ...
Protein kinases (PKs) have emerged as one of the most intensively investigated drug targets in current pharmacological research, with indications ranging from oncology to neurodegeneration. Tau protein hyperphosphorylation was the first pathological post-translational modification of tau protein described in A...
Metastasis can also occur aftercancer treatment. This happens when cancer cells are dormant during treatment—drugs may not "see" those cells. These invisible cells can remain hidden in the body, only to wake up and begin growing into a new cancer months or even years later. For patients who...
Triple negative breast cancer, so-called because thecancer cellsare not fueled by estrogen, progesterone or the HER2 protein, is harder to treat and more likely to spread to other parts of the body. Previous research has suggested that adding an immunotherapy treatment tochemotherapybefore surgery ...
Scottish Folds are healthy cats, but some illnesses like cancer can strike even the toughest. There is also an ever-present risk of an accident, especially with cats who like climbing or going outside. A single broken bone can cost hundreds or thousands of dollars to fix, and many cats ...
Cells with deletions within WWOX-encoding gene (depicted as Δ) are positively selected owing to the role of WWOX in DDR leading to genomic instability and mutator phenotype. Additional mutations in other tumor suppressor loci (such as p53) would release antitumor barriers leading to cancer ...
Inflammation has a major role in atherosclerosis and the acute phase C-reactive protein (CRP) is elevated after acute myocardial infarction. Inflammation i... SN Psychari,TS Apostolou,EK Iliodromitis,... - 《Hellēnikē Kardiologikē Epitheōrēsē》 被引量: 44发表: 2007年 The Pattern of Inf...
2017). For both ODM chemically synthesized oligonucleotide and ‘DNA-free’ delivery, RNA expressing the SDN module or the protein (TALEN, ZFN) or ribonucleoprotein complex (in case of CRISPR-Cas) itself can be delivered directly into plant cells (Metje-Sprink et al. 2018; Okuzaki and ...
Immunotherapy is a treatment strategy that boosts a patient's immune system to attackcancerous cells. In this novel study led by Ryan Teague, Ph.D., professor of molecular microbiology and immunology at Saint Louis University's School of Medicine, the Teague lab studied T cell responses and an...
Protein targets of acrylamide adduct formation in cultured rat dopaminergic cells Toxicol. Lett., 219 (3) (2013), pp. 279-287 Google Scholar [163] D.S. Barber, S. Stevens, R.M. LoPachin Proteomic analysis of rat striatal synaptosomes during acrylamide intoxication at a low dose rate Toxico...