Viruses are acellular, pathogenic agents that infect and destroy a host cell. Viruses are generally made up of either DNA or RNA and a protein capsid. Unlike microorganisms which can replicate on their own, viruses can only replicate inside a host cell. The first discovered virus was th...
PB1-F2 protein, the 11th influenza A virus (IAV) protein, is considered to play an important role in primary influenza virus infection and postinfluenza secondary bacterial pneumonia in mice. The functional role of PB1-F2 has been reported to be a strain-specific and host-specific phenomenon....
SV40 was subsequently demonstrated to be a carcinogenic virus in experimental and animal models. Since then, the SV40 oncogenic protein large T antigen (SV40 Tag) has been shown to cause malignant transformation of asbestos-treated human pleural mesothelial cells and malignant pleural mesothel...
The herpes simplex virus type 1 (HSV-1) α protein ICPO trans-activates HSV-1 early genes in transient expression assays. To investigate the function of ICP0 during HSV-1 infection, we have lowered the level of ICP0 by use of a recombinant plasmid that has been engineered to express the...
Incorporation of Vpr into human immunodeficiency virus type 1 virions: requirement for the p6 region of gag and mutational analysis. The product of the vpr open reading frame of human immunodeficiency virus type 1 (HIV-1) is a 15-kDa, arginine-rich protein that is present in virions in m...
How does a DNA virus enter the cell? Does an RNA virus have DNA? Why doesn't an RNA virus have methylation? How are DNA and RNA involved in protein synthesis? What RNA virus replicates in the nucleus? How does a DNA virus enter a eukaryotic cell?
C. It also releases T-cells, which work to kill the virus. D. And some viruses, such as HIV, work by tricking the immune system. E The human body does have some natural defenses against a virus. F Like our ide a of Napoleon, viruses are very small.G. Once a virus infects a ...
The cellular factors that mediate foamy virus (FV) latency are poorly understood. In this study we show that the only known inhibitor of FV replication, the promyelocytic leukemia protein (PML), which binds the FV transactivator (Tas), does not play an important role in FV latency in vitro....
The second phase involves a slowly building loss of function that is associated with chronological age and the process of senescence2,3,4. Protein aggregation in diverse tissues increases with age in Caenorhabditis elegans5,6,7 and Drosophila melanogaster8. Concomitantly, researcher have observed ...
Irisin, derived from the proteolytic processing of fibronectin type III domain-containing protein 5 (Fndc5), is a well-studied myokine with beneficial effects on metabolism. This study explored the feasibility of adeno-associated virus (AAV)-mediated Fndc5 gene therapy to treat obesity in a mouse...