Result 1. Buntanetap is a translational inhibitor of APP by pulse-chase experiment in mice and by stable isotope labeling kinetics (SILK) in humans (Galasko et al. 2022). Conclusion In all our studies conducted to date in AD mice and humans, we have obtained consistent ...
In a father-son pair of short sleepers, the researchers identified amutation in another gene, NPSR1, which is involved in regulating the sleep-wake cycle. When they created mice with the same mutation, they found that the animals spent less time sleeping and, in behavioral tests, lacked the...
et al. Rosiglitazone rescues memory impairment in Alzheimer’s transgenic mice: mechanisms involving a reduced amyloid and tau pathology. Neuropsychopharmacology 35, 1593–1604 (2010). CAS PubMed PubMed Central Google Scholar Yamanaka, M. et al. PPARγ/RXRα-induced and CD36-mediated microglial...
Long-term oral carcinogenicity studies of TDF in mice and rats were carried out at exposures up to approximately 16 times (mice) and 5 times (rats) those observed in humans at the therapeutic dose for HIV-1 infection. At the high dose in female mice, liver adenomas were increased at expos...
aMeetings, Incentives, Conventions and Exhibitions (MICE) Rates 会议、刺激、大会和陈列 (老鼠) 率[translate] aowner of the house 房子的所有者[translate] asocking out 殴打[translate] aBody size, physical activity, and risk of triple-negative and estrogen receptor-positive breast cancer. 身体尺寸、...
(Fr, 2019), MICE Mostra Internacional de Cinema Etnográfico (Es, 2019), ISA Universidad de las arts / Bienal de la Habana (Cu, 2019), Parana International Film Festival (Ar, 2019),Eureka Festival Universitario de Cine(Co, 2019), Tauary (Br, 2019), Tefé (Br, 2019),Agosto Foundation...
Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1. Nature 383, 710–713 (1996). CAS PubMed Google Scholar Citron, M. et al. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice...
Wld(s) mice have a triplication of the fusion gene Ube4b/Nmnat and a phenotype of axon protection. Wld(s) mice develop an attenuated disease course of EAE, with decreased demyelination, reduced axonal pathology, and decreased CNS macrophage and microglial accumulation. The attenuated disease in ...
aleppicum 341.4 C20H23NO4 Toxic in mice (115 mg/kg) Barakat et al. (2016) 6 Corydine N-oxide G. paucilobium 357.405 C20H23NO5 Karimova et al. (1980) 7 (S)-Corytuberine Glaucium spp. 327.379 C19H21NO4 Inhibit the proliferation of BALB/c mouse B cellsIC50: 21.3 μMInhibit ...
humans and experiments performed in AD transgenic mice have revealed that enhanced social, mental and physical activity (enriched environment) in elderly people/aged animals protects against dementia and AD (Fratiglioni et al.2004; Arendash et al.2004; Jeong et al.2011). It would be attractive...