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Alzheimer’s disease (AD) is a neurodegenerative disorder that is the most common cause of dementia and currently has few clinically efficacious disease modifying therapies [1]. In order to develop disease modifying therapies, it is imperative to better understand the mechanisms of disease initiation ...
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Alzheimer’s disease (AD) is a neurodegenerative disorder that is the most common cause of dementia and currently has few clinically efficacious disease modifying therapies [1]. In order to develop disease modifying therapies, it is imperative to better understand the mechanisms of disease initiation ...
Imaging brain cholinergic activity with positron emission tomography: its role in the evaluation of cholinergic treatments in Alzheimer's dementia. One of the strategies in the treatment of Alzheimer's disease is the use of drugs that enhance cholinergic brain function, since it is believed that cho...
What: AD is uniquely human, but molecular mechanisms can be measured in Tg mice. • Who: A universal biological variable of AD, APOE is critical for preclinical models. • How: There are several strategies for developing APOE-Tg mice. • When/Where: Developmental and region-specific mode...
Glenberg. “Normally, the brain would be sending signals to the periphery to frown, and the extent of the frown would be sent back to the brain. But here, that loop is disrupted, and the intensity of the emotion, and of our ability to understand it when embodied in language, is ...
Increasing evidence suggests that inflammatory and immune components in brain are important in Alzheimer’s disease (AD) and anti-inflammatory and immunotherapeutic approaches may be amenable to AD treatment. It is known that complement activation occurs
For a future or current practitioner of machine learning, it’s important to be able to recognize the signal amid the noise, so that you can tell world-changing developments from overhyped press releases. Our future is at stake, and it’s a future in which you have an active role to ...
It is nowadays a common practice to “work without sleep and catch up later.” It is not a good idea to keep up with sleep deficit. In recent years, several reports have shown that the consequences of chronic sleep loss are not reversible. It may...