DNA-PK抗体是针对DNA依赖性蛋白激酶(DNA-PK)这一特定蛋白质的特异性抗体。DNA-PK是一种在DNA双链断裂(DSB)修复过程中起关键作用的核蛋白复合体。它主要参与非同源末端连接(NHEJ)这一DNA修复途径,对于维持基因组的稳定性和防止细胞癌变至关重要。 DNA-PK复合体由三个亚基组成:催化亚基DNA-PKcs(也称为PRKDC)、Ku...
DNA-PK复合体由三个亚基组成:催化亚基DNA-PKcs(也称为PRKDC)、Ku70(也称为XRCC6)和Ku80(也称为XRCC5)。当DNA发生双链断裂时,DNA-PKcs与Ku70/Ku80异二聚体结合,形成有活性的DNA-PK复合体。该复合体随后参与NHEJ过程,将断裂的DNA末端连接起来。
本公司经销phospho-DNA PK/PRKDC(Thr2609),磷酸化DNA依赖性蛋白激酶抗体,克隆类型为polyclonal,宿主来源是Rabbit,phospho-DNA PK/PRKDC(Thr2609)磷酸化DNA依赖性蛋白激酶抗体可应用于WB、elisa、IP、IF、IHC等实验,欢迎垂询订购!货号:BY-3735R英文名称:Anti-phospho-DNA PK/PRKDC(Thr2609)中文名称:磷酸化DNA依赖性...
产品名称:PRKDC / DNA-PK .0订购此产品 供应商:Epitomics 规格:100μl 目录价:3050 库存状态: CAS编号: 应用范围: 种属来源: 相关信息: 保存条件: 说明书地址:点击查看详细 打印此页关闭此页 上一个:4E-BP1 [1578-1/100μl] 下一个:Histone Deacetylase 3 (C-term)[1580-1/100μl]...
of these are components of a protein complex termed the DNA-dependent protein kinase (DNA-PK), of which two (G22p1, also known as Ku70, and Xrcc5, also known as Ku80) are subunits of the Ku protein and the third is a large catalytic component termed Prkdc (also known as Prkdc). ...
技术支持 货号PA5-29023 CNY4,312.00 100 µL 下单后预计有货时间 07-Apr-2025 查看价格 批量或定制请求 Application Created with Sketch. 图:1/5 DNA-PK Antibody (PA5-29023) in ICC/IF Immunofluorescence analysis of DNA-PK was performed using 70% confluent log phase HeLa cells. The cells were...
Upon sensing cytosolic DNA, the enzyme cGAS induces innate immune responses that underpin anti-microbial defenses and certain autoimmune diseases. Missense mutations of PRKDC encoding the DNA-dependent protein kinase (DNA-PK) catalytic subunit (DNA-PKcs)
NRG mice (retaining an intact PRKDC gene) were injected with AML cells obtained from a patient whose AML relapsed after four prior treatments and stem cell transplantation. After engraftment, mice were treated with either vehicle, M3814, CPX-351, or CPX-351 + M3814 (Fig. 7A). The ...
NCBI Gene SymbolPRKDC Database Links Gene ID:5591Swiss-Prot #:P78527 OMIM #:600899Unigene #:Hs.491682 Target ModificationUnmodified/Total Modification Sites Application Images Image 1 Immunofluorescence analysis of HeLa cells, using DNA-PK Antibody. The picture on the right is blocked with the synt...
DNA依赖性蛋白激酶也被称为DNA-PKcs,是一种酶,在人中由编码基因命名为PRKDC或XRCC7。DNA-PKcs属于磷脂酰肌醇3-激酶相关激酶蛋白家族。DNA-Pkcs蛋白是丝氨酸/苏氨酸蛋白激酶,其包含4,128个氨基酸的单个多肽链。DNA-PKcs是核DNA依赖性丝氨酸/苏氨酸蛋白激酶的催化亚基,称为DNA-PK。第二种成分是自身免疫抗原Ku。就...