12. We found that, like TRAF3, TRAF2 also played an important role in positively regulating the RNA pathway and suppressing the DNA pathway. While the cIAP1 and cIAP2 components have been previously shown to mediate
RNA and RNA:DNA nucleases can be also be analysed in real-time We have established a straightforward and robust assay that can measure DNA nuclease activity. To expand the potential of this assay to include RNA nucleases, we employed the use of an alternative RNA-sensitive fluorescent dye avail...
antibodies targeting mouse PD1 and human p53 mutant R282W (p53R282W). We performed single-cell RNA sequencing (scRNA-seq) to investigate the mechanisms underlying the enhanced immunity mediated by spike immunization or intratumoral delivery of anti-p53R282Wantibodies. These studies demonstrate that ...
ActivityVirus proteinEncoded by genome segment RNA-dependent RNA polymerase (RdRp) λ3 L3 RNA triphosphatase μ2 M1 Guanyltransferase (capping enzyme) λ2 L2 Methyltransferase λ2 L2 Helicase (Hel) λ1 L1 Class IV: Single-stranded (+)sense RNA This type of genome occurs in many animal viruses...
团队在嗜盐古菌Natronobacterium gregoryi内发现了锌指核酸酶(NgAgo),NgAgo是一种未被识别的pAgo类型核酸内切酶,可以结合单链DNA或RNA分子作为引导分子,定向切割互补的靶标DNA、RNA,具有高度特异性和灵活性,可用于精确编辑基因序列,具有很大的潜在应用价值。
(a) Nick-sealing activity, (b) cohesive-end ligation, and (c) blunt-end ligation. In (b) and (c), the 5′-P and 3′-OH termini to be ligated or that have been ligated are denoted by small filled circles. The covalent joining of polynucleotides catalyzed by the DNA ligase is a ...
在临床治愈组中,肝内HBsAg阴性患者的肝内HBV RNA水平显著低于肝内HBsAg阳性患者(0.98 [0.00 - 1.87] vs. 3.87 [2.24 - 4.71] log copies/103 cells,p = 0.013)。临床治愈组中肝内HBsAg阴性的总HBV RNA reads数显著低于肝内HBsAg阳性的患者(24 [7.50 - 58] vs. 4751 [1726 - 24,486],p = 0.0...
displaced DNA strand. They are shown to be resistant to the activity of DNA methyltransferases. The formation of DNA:RNA hybrids has been associated with a number of neurological diseases. Mutations in the DNA:RNA helicase senataxin (SETX) are implicated in the dominant juvenile form of amyotrophi...
cells105. Furthermore,HERV-Kelements have been implicated in insertional mutagenesis. Recent studies have identifiedHERV-Kinsertions with potential mutagenic effects on nearby genes, including cancer-related genes106(Supplementary Fig.S7(b)). Human cancers have also exhibited somatic activity, with ...
The application also searches RNA motifs such as polyadenylation site or RNA–protein binding motifs as well as DNA motifs such as enhancers as well as user-specified motif combinations (https://bioinfo-wuerz.de/aimodules/; alternative entry pages: https://aimodules.heinzelab.de or https://...