cells and many viruses. It consists of two strands of nucleotides linked together in a structure resembling a ladder twisted into a spiral. In eukaryotic cells, the DNA is contained mainly in the nucleus and mitochondria. DNA can replicate itself and synthesize RNA. CompareRNA. See Note atgene...
J. Ku protein targeting by Ku70 small interfering RNA enhances human cancer cell response to topoisomerase II inhibitor and gamma radiation. Mol. Cancer Ther. 4, 529–536 (2005). CAS PubMed Google Scholar Malik, M. & Nitiss, J. L. DNA repair functions that control sensitivity to ...
Decreased frequency and highly aberrant spectrum of ultraviolet-induced mutations in the hprt gene of mouse fibroblasts expressing antisense RNA to DNA polymerase zeta. Mol. Cancer Res. 1, 836–847 (2003). CAS PubMed Google Scholar Sonoda, E. et al. Multiple roles of Rev3, the catalytic ...
In a transcription factor, a motif-specific DNA binding factor controls the rate of the transcription of a gene from DNA to messenger RNA by binding a protein to the DNA motif. In reference [4], we found a correlation between motifs whose subgroup structure is that of a free group and th...
Retroviruses (12) are RNA viruses whose life cycle involves genomic integration, permitting long-term and inheritable expression of a gene shuttled by this virus. The simplicity of retroviral genomes has allowed the development of replication-free, clinically safe retroviral vectors. Unfortunately, ...
非整倍性是一种以染色体获得/丢失及蛋白质组失衡为特征的基因组状态,需在RNA和蛋白水平上加以调节以“缓冲”DNA拷贝数改变(CNA)的影响,即实现剂量补偿,但很明显,在人类非整倍体癌细胞中这种缓冲效果并未达到预期。最近的研究表明非...
The term “cancer immunotherapy” refers to a set of treatment methods that involve either the modification of the immune system of the host or the employment of immune system components to combat cancer. Cytokines, immune cells, and monoclonal antibodies are a few examples of immune system ...
These structural differences help us understand the diverse functions of DNA in long-term genetic storage and RNA in protein synthesis and genetic transmission. See below for more of the key similarities and differences between DNA, which stands for deoxyribonucleic acid, and RNA, or ribonucleic acid...
RNA (mRNA), which will later undergo the process of translation. Alternatively, the transcribed gene may encode transfer RNA (tRNA), which carries specificamino acidsto the ribosome for incorporation into the growing protein chain during translation. Another type of RNA synthesized from genes in ...
DNA is precipitated from the phenol phase and interphase of samples that have been homogenized (or lysed) in 1 ml of TRI Reagent (step 5 in the RNA Isolation Protocol). After a series of washes to remove residual phenol, the DNA pellet ...