Schematics of DNA and RNA structures.AThe canonical right handed double helix, also known as B DNA secondary structure.BZ-DNA forms a left-handed double helix.CG-quadruplexes are formed by the stacking of multiple G-quartets held together by Hoogsteen hydrogen bonds (top). Four guanines establis...
The field of microbiome research has evolved rapidly over the past few decades and has become a topic of great scientific and public interest. As a result of this rapid growth in interest covering different fields, we are lacking a clear commonly agreed definition of the term “microbiome.” M...
With the rapid emergence of RNA databases and newly identified non-coding RNAs, an efficient compression algorithm for RNA sequence and structural information is needed for the storage and analysis of such data. Although several algorithms for compressing DNA sequences have been proposed, none of the...
and thymidine kinase 1 (TK1), have potential as diagnostic tools and as prognostic factors in assessing cancer treatment and disease progression. TK1 is involved in cellular proliferation through the recovery of the nucleotide thymidine in the DNA salvage pathway. TK1 upregulation has been found to ...
In the past decades, DNA microarrays have been used extensively to quantify the abundance of mRNA corresponding to different genes, and more recently high-throughput sequencing of cDNA (RNA-seq) has emerged as a powerful competitor. As the cost of sequencing decreases, it is conceivable that the...
Application and meaning of DNA barcoding The selected DNA barcode for Asteraceae, ITS2, is not perfect, especially for taxonomists and phylogenetic experts. However, even an imperfect barcode can have a major effect on many areas of research and be sufficient for many applications [13]. For in...
Annotators were encouraged to crosscheck information to ensure that the annotations reflected the meaning of the text and were consistent with the guidelines. Annotators were free to reference other sources as needed, including chemical databases (ChEBI, DrugBank, PubChem, etc.) or to search for ...
Endogenous expression of L1 mRNA is the first step in an L1-initiated mutagenesis event. However, the contribution of individual cell types to patterns of organ-specific L1 mRNA expression remains poorly understood, especially at single-locus resolution.
meaning when different sets of interactions (hence processes) evolved, and whether these interactions were evolutionarily stable.AncientandContemporaryrefer to the relative age of the sub-graphs, identifying new clade-specific relationships (here called refinement); introgression indicates that a component,...
gene or protein identifiers are rapidly annotated and summarized according to shared categorical data for Gene Ontology, protein domain, and biochemical pathway membership. DAVID assists in the interpretation of genome-scale datasets by facilitating the transition from data collection to biological meaning...