^abSale JE. Translesion DNA synthesis and mutagenesis in eukaryotes. Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a012708. ^Pilzecker B, et al. DNA damage tolerance in stem cells, ageing, mutagenesis, disease and cancer therapy. Nucleic Acids Res. 2019 Aug 22;47(14):7163-7181 ^Lar...
The molecular basis of sensitivity of ionizing radiation and other damaging agents is not clearly defined in eukaryotes. While a large number of mutants have been described only a few have been demonstrated to have a defect in the repair of damage to DNA. An interesting characteristic of a sub...
通过该复制,侵入链3'端不断延伸,供体双链中的同源链不断被置换,D环不断增长(此种修复性DNA复制被称为“链置换DNA合成反应”[strand displacement DNA synthesis reaction](98)),在DSBR初期被RecBCD降解掉的DNA序列重新得到合成。最终,延伸的侵入3'链与(由同一DSB造成的)另一DSE中的5'链连接,从而导致Holliday...
In their seminal publication describing the structure of the DNA double helix 1, Watson and Crick wrote what may be one of the greatest understatements in the scientific literature, namely that “It has not escaped our notice that the specific pairing we
2007. Send in the clamps: Control of DNA translesion synthesis in eukaryotes. Mol Cell 28:522-529.Jansen JG, Fousteri MI, de WN. Send in the clamps: control of DNA translesion synthesis in eukaryotes. Mol Cell 2007;28:522 - 9.
In eukaryotes, the vast bulk of DNA synthesis takes place during the S phase of the cell cycle, and the entire genome must be unravelled and replicated in order to produce two daughter copies of the organism. It takes three essential phases for DNA replication to occur: first, the opening...
In eukaryotes, the leading strand DNA polymerase Polε synthesises the DNA with higher processivity when in complex with the DNA clamp PCNA. Here, the authors report two cryo-EM structures of human Polε bound to the PCNA clamp and a DNA substate, revealing the conformational changes associated...
Functions for REV3L and REV7(MAD2B) in higher eukaryotes have been suggested not only in translesion DNA synthesis but also in some forms of homologous... GN Gan,JP Wittschieben,BØ Wittschieben,... - 《Cell Research》 被引量: 237发表: 2008年 ...
In eukaryotes, DNA is contained in the cell nucleus, a large membrane-bound compartment. 在真核生物中,DNA被包含细胞核种,细胞核是一巨大的膜结构闭合体。 Biologists in the 1940s had difficulty in conceiving how DNA could be the genetic material. ...
Replication in eukaryotes starts at multiple origins of replication. The mechanism is quite similar to that in prokaryotes. A primer is required to initiate synthesis, which is then extended by DNA polymerase as it adds nucleotides one by one to the growing chain. The leading strand is synthesize...