ResearchOpen Access16 Sept 2024 Nature Communications Volume: 15, P: 8102 Structures of the human leading strand Polε–PCNA holoenzyme In eukaryotes, the leading strand DNA polymerase Polε synthesises the DNA with higher processivity when in complex with the DNA clamp PCNA. Here, the authors...
This review commemorates the 40th anniversary of DNA sequencing, a period in which we have already witnessed multiple technological revolutions and a growth in scale from a few kilobases to the first human genome, and now to millions of human and a myria
DNA sequencing Manual techniques to sequence DNA were devised in the 1970s; however, sequencing the human genome was made possible by the development of automated sequencing technology. This technology continues to play an important role in the rheumatology research laboratory and is beginning to be ...
出版商网址:http://www.oxfordjournals.org 简介 期刊简称DNA RES 参考译名《DNA研究》 核心类别SCIE(2022版), 外文期刊, IF影响因子4.009 自引率1.80% 主要研究方向生物学-GENETICS & HEREDITY 遗传学 DNA RESEARCH《DNA研究》(双月刊). DNA Research is an internationally peer-reviewed journal which aims at...
Recent research indicates a mechanism by which an early driver mutation may cause subsequent epigenetic alterations or mutations in pathways leading to cancer. Wang et al. [134] point out that isocitrate dehydrogenase genes IDH1 and IDH2 are the most frequently mutated metabolic genes in human cance...
DNAzyme is a class of DNA molecules that can perform catalytic functions with high selectivity towards specific metal ions. Due to its potential applications for biosensors and medical therapeutics, DNAzyme has been extensively studied to characterize the relationships between its biochemical properties an...
Recent studies, generated through humancancer genome sequencingprojects,30have demonstrated that some tumors, primarilymelanomasandsquamous cell lung cancers, have elevated levels of random point mutagenesis. This elevatedpoint mutationsignature indicates that these tumors (1) may have an underlying dysregula...
NEXT-GENERATION DNA SEQUENCING (NGS) Sequencher empowers the benchtop scientist by bringing the latest peer-reviewed NGS algorithms out of the command line and into an intuitive point and click interface. Whether performing reference-guided alignments, de novo assembly, variant calling, or SNP analyse...
Determined by sequencing the Y chromosome. A test of discovery that continues to provide additional value as more men test and new haplogroups are formed. Big Y-700 haplogroups generally fall into a genealogically useful timeframe and can be very recent. The Discover tool and Time Tree provide...
Johann Elbaz ,Oleg Lioubashevski &Itamar Willner Browse broader subjects DNA nanotechnology Browse DNA computing across other nature.com journals Nature Nanotechnology (Nat. Nanotechnol.)ISSN1748-3395(online)ISSN1748-3387(print)