在 1978 年的一篇短文中,美国科学家沃特·吉尔伯特(Walter Gilbert)提议用“intron(内含子)”指代 mRNA 前体中的非编码序列。mRNA 是基因由 DNA 序列“翻译”成蛋白质序列的模板。 1980 年,吉尔伯特与弗雷德里克·桑格(Frederick Sanger)、保罗·伯格(...
在1978年的一篇短文中，美国科学家沃特·吉尔伯特（Walter Gilbert）提议用“intron（内含子）”指代mRNA前...
Response to Parry et al.: Strong evidence for genomic integration of SARS-CoV-2 sequences and e...
A M Freund, B Bichara, R P Fuchs. Z-DNA-forming sequences are spontaneous deletion hot spots. Proc Natl Acad Sci U S A. 1989 Oct; 86 (19): 7465-9. A R Chowdhury, R Bakshi, J Wang, G Yildirir, B Liu, V Pappas-Brown, G ...
def dna_to_protein(dna_sequence): protein = "" # 确保DNA序列长度是3的倍数 if len(dna_sequence) % 3 != 0: raise ValueError("DNA sequence length must be a multiple of three.") # 遍历DNA序列,每三个核苷酸一组 for i in range(0, len(dna_sequence), 3): ...
⑥ 你如果觉得自己去把外显子拼起来得到CDNA序列的话,那你就out了,在NCBI Reference Sequences (RefSeq)这个选中,有 NG、NM、NP 这些你熟悉或者不熟悉的缩写,mRNA and protein(s)这里面,有剪接体的简介、剪接体之间的不同,有几个就会报道几个,很全。然后,重点是有个CCDS 这个链接,点进去 ...
Mehta A. et.al.(1998) A sequence-specific RNA binding protein complements Apobec-1 to edit apolipoprotein B mRNA.Mol.Cel.Biol.18(8):4426-4432. Nordhoff E. et al.(1999).Rapid identification of DNA-binding proteins by mass spectrometry.Nat. Bi...
2). Transcription factors alter the rate of transcription of DNA sequences into mRNA by binding to the DNA and increasing the ability of the transcriptional machinery responsible for formation of mRNA. This control mechanism for mRNA production may be the most important cause of variability in ...
Hansen-Hagge TE. et.al.(2001)Identification of sample-specific sequences in mammalian cDNA and genomic DNA by the novel ligation-mediated subtraction (LIMES).Nucl.Acids Res.29(4):e20. Pradel N. et.al.(2002)Genomic subtraction to identify and characteriz...
[2]Analysis of the genome sequence of the flowering plant Arabidopsis thaliana 2001年:绘制完成人类基因组草图 [3] 1990年启动的人类基因组计划(Human Genome Project, HGP)致力于确定人类基因组的所有DNA碱基序列,以获得人类的“基因蓝图”。2001 年,两篇重要论文报道了通过鸟枪测序法获得的人类基因组序列初稿,...