NextGen Sequence Analyzer An efficient and easy to use FastQ/SFF viewer, editor, filter and converter. NextGen Workbench is the first and the only complete FastQ/SFF editor with graphic interface on the entire bioinformatics market! The program can process huge FastQ/SFF files even when running...
DNA methylation is a crucial epigenetic mark for activity-dependent gene expression in neurons. Very little is known about how synaptic signals impact promoter methylation in neuronal nuclei. In this study we show that protein levels of the principal de
Aging is associated with multiple cellular changes that are often tissue specific1. Cytosine methylation, however, stands out, as it allows for the development of pan-tissue aging clocks (multivariate age estimators) that are applicable to all human tissues2,3,4. The subsequent development of simi...
The partial amino acid sequence (from left to right, C-terminal to N-terminal) deduced from y ions is shown on the spectrum. The mass difference between y9 and y8 ions (G) or y8 and y7 ions (H) is the mass of the acetyl-d3-modified lysine residue. Anti-His blots (A and B) ...
Recently, transcriptome analysis has been used to identify differentially expressed genes (DEGs) under metal exposure. For example, DEGs involving in the respiratory chain and stress responses have been identified in scallops under copper (Cu) exposure13. Previously, we conducted RNA sequence (RNA-...
PARK19 mutations of human DNAJC6 were verified using DNA sequencing, and cDNA encoding wild-type (WT), Q789X or R927G DNAJC6 was subcloned into a pcDNA3 expression vector containing a FLAG-tag sequence. Then, the cDNA of the FLAG-tagged WT or mutant DNAJC6 was transfected to ...