Biochemical studies on the replication of the genome of the small DNA virus simian virus 40 (SV40) have resulted in the identification of a number of DNA replication proteins from human cells. One of these, Replication Protein A (RPA), was phosphorylated in a cell cycle-dependent manner, ...
A. Interphase B. Prophase C. Metaphase D. Anaphase 相关知识点: 试题来源: 解析 A。细胞周期中,间期负责 DNA 复制。间期包括 G1 期、S 期和 G2 期,其中 S 期进行 DNA 复制。前期(B 选项)主要是染色体出现等变化。中期(C 选项)染色体排列在赤道板上。后期(D 选项)姐妹染色单体分离。
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2. Hartwell, L. H. & Weinert, T. A. Checkpoints: controls that ensure the order of cell cycle events.Science246, 629–634 (1989). 3. Magiera, M. M., Gueydon, E. & Schwob, E. DNA replication and spindle checkpoints cooperate during S phase to delay mitosis and preserve genome ...
DNA Replication DNA and certain proteins known as histones form the chromosomal structures. The DNA is double-stranded and forms a tightly coiled package with the assistance of the histones. During interphase, the chromosomes relax, giving replication enzymes access to create a new copy of each chr...
3. DNA损伤的类型 3.1 内源性DNA损伤3.2 外源性DNA损伤 4. DNA损伤与DNA变异 5. DNA损伤应答(DDR)途径 5.1 DNA修复机制5.2 细胞周期停滞与细胞凋亡 6. DNA损伤与疾病 7. 与DNA损伤修复相关的重组蛋白 1. 什么是DNA损伤?DNA损伤是指任何偏离其原始双螺旋结构的改变。所有细胞生物都会发生DNA损伤。2....
Stress-Induced Mutagenesis: Implications in Cancer and Drug Resistance. Annu Rev Cancer Biol. 1: 119–140. (24)Mehta A, Beach A, Haber JE. 2017. Homology requirements and competition between gene conversion and break-induced replication during double-strand break repair. Mol Cell. 65:515–526...
in prokaryotes. In contrast, eukaryotic chromosome replication requires the orchestration of multiple DNA replication origins to ensure that each DNA polymer, irrespective of its size in the cell, is replicated exactly once duri...
Geminiviruses: Models for Plant DNA Replication, Transcription, and Cell Cycle Regulation Geminiviruses have small, single-stranded DNA genomes that replicate through double-stranded intermediates in the nuclei of infected plant cells. Viral dou... L Hanley-Bowdoin,SB Settlage,BM Orozco,... - 《...
[12] Rando T A. The immortal strand hypothesis: segregation and reconstruction[J]. Cell, 2007, 129(7): 1239-1243. [13] Xing M, Zhang F, Liao H, et al. Replication stress induces ATR/CHK1-dependent nonrandom ...