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The gene repair process is initiated to address DNA damage, and radiation is the most common exogenous factor causing such damage, which can destroy the integrity of the genome. At present, there are at least five DNA damage repair pathways known, namely, base excision repair, nucleotide excisio...
Also DNA double-strand breaks may be repaired by an inaccurate repair process leading to mutations. In addition, a double strand break can cause rearrangements of the chromosome structure (possibly disrupting a gene, or causing a gene to come under abnormal regulatory control), and, if such a ...
DNA–protein crosslinks (DPCs) induced by aldehydes interfere with replication and transcription. Hereditary deficiencies in DPC repair and aldehyde clearance processes cause progeria, including Ruijs–Aalfs syndrome (RJALS) and AMeD syndrome (AMeDS) in
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Lloyd. DNA double strand break repair and crossing over mediated by RuvABC resolvase and RecG translocase. 2008. DNA Repair (Amst.) 7:1517–1530. (125)Masai, H. et al. 1994. Escherichia coli PriA protein is essential for inducible and constitutive stable DNA replication. EMBO J. 13, ...
The outcome of CRISPR-Cas-mediated genome modifications is dependent on DNA double-strand break (DSB) processing and repair pathway choice. Homology-directed repair (HDR) of protein-blocked DSBs requires DNA end resection that is initiated by the endonuc
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P. DNA double-strand break repair: from mechanistic understanding to cancer treatment. DNA Repair (Amst.) 6, 923–935 (2007). CAS Google Scholar Collis, S. J., DeWeese, T. L., Jeggo, P. A. & Parker, A. R. The life and death of DNA-PK. Oncogene 24, 949–961 (2005). CAS...