DNA–protein crosslinks (DPCs) induced by aldehydes interfere with replication and transcription. Hereditary deficiencies in DPC repair and aldehyde clearance processes cause progeria, including Ruijs–Aalfs sy
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核苷酸切除修复(nucleotide excision repair,NER)能够修复链内交联损伤、一部分DNA-蛋白质交联(DNA-protein crosslinking, DPC)损伤,甚至一部分异常碱基。 图组:紫外线照射DNA产生「嘧啶二联体」损伤 这是最经典和最常见的DNA损伤,是一种链内交联,也即是通过NER途径所修复;而甲醛会引发类似的损伤,也能够通过NER途径...
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Role of the yeast DNA repair protein Nej1 in end processing during the repair of DNA double strand breaks by non-homologous end joining. DNA Repair (Amst.). 31, 1–10 (2015). Article Google Scholar Akopiants, K. et al. Requirement for XLF/Cernunnos in alignment-based gap filling by ...