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Also DNA double-strand breaks may be repaired by an inaccurate repair process leading to mutations. In addition, a double strand break can cause rearrangements of the chromosome structure (possibly disrupting a gene, or causing a gene to come under abnormal regulatory control), and, if such a ...
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一旦形成光损伤,细胞会通过光致复活作用(photoreactivation)和核苷酸切除修复途径(nucleotide excision repair,NER)进行修复。在光致复活作用中,单个光解酶利用光子产生的能量逆转损伤。CPD 和 (6-4)PP 特异性的光解酶(photolyase)已在细菌、酵母、昆虫、植物和有袋哺乳动物中鉴定出来;而在其他哺乳动物(包括人类)中,尚...
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DNA–protein crosslinks (DPCs) induced by aldehydes interfere with replication and transcription. Hereditary deficiencies in DPC repair and aldehyde clearance processes cause progeria, including Ruijs–Aalfs syndrome (RJALS) and AMeD syndrome (AMeDS) in