DNA origami structuresframework structuresmolecular programmingself-assemblyDesigner DNA architectures with nanoscale geometric controls provide a programmable molecular toolbox for engineering complex nanodevices. Scaffolded DNA origami has dramatically improved our ability to design and construct DNA nanostructures ...
Assembly and Microscopic Characterization of DNA Origami StructuresDNA nanotechnologyDNA origamiAFMSuper-resolution imagingDNA origami is a revolutionary method for the assembly of molecular nanostructures from DNA with precisely defined dimensions and with an unprecedented yield. This can be utilized to ...
7. Endo M, Sugita T, Rajendran A, et al. Two-dimensional DNA origami assemblies using a four-way connector. Chem. Commun. 47, 3213-3215 (2011) 8. Zhao Z, Liu Y, Yan H. Organizing DNA origami tiles into larger structures using preformed scaffold frames. Nano Lett. 11, 2997-3002 (2...
Barcoded DNA origami structures for multiplexed optimization and enrichment of DNA-based protein-binding cavities Multivalent binding is a common strategy to enhance the interactions between weak binding partners. Now, following this principle, DNA origami scaffolds have been used to arrange DNA aptamers...
We divided this workflow into two parts: (1) using a YOLOv5 DNN to detect the DNA origami structures from raw TEM images, and (2) then using a Resnet50 DNN to detect the conformation from individual particle images. In the particle detection process, we used a small training set (9 ...
Although DNA origami structures are a promising material for interfacing biological systems, they suffer from instability, especially in the presence of DNA-degrading enzymes. In experiments, however, “we can clearly observe that the protein layer efficiently protects the encapsulated DNA nanos...
利用马克?巴特的算法DAEDALUS (DNA OrigamiSequence Design Algorithm for User-defined Structures)制作的DNA三维结构。 图片来源:MIT News 实际上,该项技术突飞猛进的历史只用了短短不到10年。2006年,随着加州理工的保罗?罗特蒙德(Paul Rothmund)一篇《自然》杂志论文的问世,2维平面上的DNA折纸技术(DNA origami)诞生...
Degradable Newkome‐type and polylysine dendrons functionalized with spermine surface units are used to control the formation of DNA origami structures. The intact dendrons form polyelectrolyte complexes with the scaffold strands, therefore blocking the origami formation. Degradation of the dendron with ...
利用马克•巴特的算法DAEDALUS (DNA OrigamiSequence Design Algorithm for User-defined Structures)制作的DNA三维结构。 图片来源:MIT News 实际上,该项技术突飞猛进的历史只用了短短不到10年。2006年,随着加州理工的保罗•罗特蒙德(Paul Rothmund)一篇《自然》杂志论文的问世,2维平面上的DNA折纸技术(DNA origami...
Size of DNA origami structures depend on scaffold length.Genome tailoring techniques can be used to create custom-made DNA origami scaffolds.DNA scaffolds of lengths ranging from ~700-nt to ~ 51,000 nt have been constructed.Smaller origami are useful to control chemical experiments in the 10–...