BS获得的 1,480,569个DMRs(Differential methylation regions),其中大部分CG型和CHG型的DMRs在叶中高甲基化,而几乎所有的CHH型DMRs在叶中低甲基化。 对每种甲基化类型分别进行甲基化水平与表达量比较和spearman相关性分析(图1),发现CG和CHG型启动子区的甲基化与基因表达负相关,CG型gene body区的甲基化与基因表达...
副教授纪冬梅,中国科学院动物研究所博士生燕蕊、博士后龙鑫为本文共同第一作者),在Nature Cell Biology发表了题为Distinct dynamics of parental 5-hydroxymethylcytosine during human preimplantation development regulate early lineage gene
42. Sendinc E, Valle-Garcia D, Dhall A, Chen H, Henriques T, Navarrete- Perea J, Sheng W, Gygi SP, Adelman K, Shi Y (2019) PCIF1 catalyzes m6Am mRNA methylation to regulate gene expression. Mol Cell 75(3):620.e9–630.e9 43. Dominissini D, Nachtergaele S, Moshitch-Moshkovitz...
图示:败血症休克EV-DNMT水平在对照组和败血症症患者中不同 (图片来源:文献原文) Extracellular vesicles (EVs) are mRNA-containing cell fragments shed into circulation during pathophysiological events. DNA methyltransferases (DNMT1, DNMT3A, and DNMT3B) regulate gene expression by modifying DNA methylation and...
核小体由H2B、H2A、H3、H4四种组蛋白(Histone)亚基各两个拷贝形成的八聚体和缠绕在外约146bp的DNA组成。其中组蛋白N端(尾部)的氨基酸残基易受到翻译后修饰(PTM),包括乙酰化(Acetylation)、甲基化(methylation)、磷酸化(phosphorylation)、泛素化(ubiquitination)等组蛋白修饰。
(lnc)RNAs in human cells and demonstrated that specific lncRNAs regulate gene expression via interactions with chromatin-modifying complexes. Here, we tested whether lncRNAs could also associate with DNA methyltransferases to regulate DNA methylation and gene expression. Using RIP-seq, we identified a ...
[15] Claycombe-Larson, K. G., Bundy, A. N., & Roemmich, J. N. (2020). Paternal high-fat diet and exercise regulate sperm miRNA and histone methylation to modify placental inflammation, nutrient transporter mRNA expression and fetal weight in a sex-dependent manner. The Journal of nutrit...
Epigenetics is emerging as an attractive mechanism to explain the persistent genomic embedding of early-life experiences. Tightly linked to chromatin, which packages DNA into chromosomes, epigenetic marks primarily serve to regulate the activity of genes. DNA methylation is the most accessible and charac...
Some gene introns harbour transposons or other repeats, which are heavily methylated in all cytosine sequences and regulate mRNA processing, for example, alternative polyadenylation. Loss of DNA methylation in a long interspersed nuclear element retrotransposon in the intron of the homeotic gene DEFICIEN...
近日,来自于加州大学圣地亚哥分校医学院、中山大学肿瘤防治中心、西京医院等研究机构的科研团队发现,DNA甲基化至少可以为4种常见癌症提供有效的分子标记,不仅仅可以准确诊断肿瘤组织,还可以作为预后的重要指标,该研究结果《DNA methylation markers for diagnosis and prognosis of commoncancers》于《PNAS》期刊在线发表。 研...