1.1 Biology of DNA Methylation DNA methylation is one of the most important epigenetic modifications, with an important role in regulating gene expression. Because this does not change the DNA sequence, normal development is ensured. It involves the addition of a methyl group (–CH3) at the 5′...
DNA methylation : molecular biology and biological significance[M] . Berlin :Brrkauser Verlag , 1993 :11Finnegan E. J., Brettel R. I. S., Dennis E. S. (1993) In 'DNA methylation: molecular biology and biological significance' ed by J. P. Jost and H. P. Saluz, Birkhauser Vedlag ...
In other words, DNAme likely controls protein-DNA interactions that facilitate gene regulation and XCI. As for the inactivation of one X-chromosome, “Randomness follows easily if the critical methylation event takes place after fertilization,” and “the differentiated state resulting from methylation ...
ResearchOpen Access10 Jan 2025Communications Biology Volume: 8, P: 38 News and Comment X-specific methylation distorts sex Despite theoretical expectations of balanced 1:1 sex ratios between females and males, many dioecious plant species exhibit sex ratio distortions. A recent study in persimmon ...
Through a genome-wide analysis of DNA methylation across 19 cell types with T-47D as reference, we identified 106,252 cell type-specific differentially-methylated CpGs categorized into 7,537 differentially (46.6% hyper- and 53.4% hypo-) methylated regions. We found 44% promoter regions and 75%...
Biochemistry and biology of DNA methylationNo abstract is available for this article.doi:10.1016/0014-5793(86)81362-XDavid ShugarFebs Letters
DNA methylation. In this review, the role of DNA methylation in body fluid identification and other DNA methylation applications are discussed. Among other applications of DNA methylation, age determination of the donor of biological evidence, analysis of the parent-of-origin specific DNA methylation ...
Gene activity is regulated by multiple mechanisms including epigenetics, such as DNA methylation [12]. Typically, methylation of promoter regions is associated with transcriptional suppression, whereas the effects of intra- and intergenic methylation on gene transcription are variable [12,13]. Historically...
DNA methylation: Molecular biology and biological significance: Edited by J. P. Jost and H. P. Saluz. Basel: Birkhäuser (1993). 572 pp. $139.50doi:10.1016/0092-8674(93)90131-9John C. Rogers
133, 134, 135, 136, 137 The identification of cell of origin is essential to stem cell biology and cancer research. As an epigenetic memory of cell origin, DNA methylation profiles will be useful in the development of regenerative medicine and tumor-type-specific and patient type-specific ...